Evidence map›Paper›PMID 31930269›Full record

ArticleChemical communications (Cambridge, England)2020

HPLC-assisted automated oligosaccharide synthesis: the implementation of the two-way split valve as a mode of complete automation.

Matteo Panza, Keith J Stine, Alexei V Demchenko

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Expediting Glycospace Exploration: Therapeutic Glycans via Automated Synthesis.Angewandte Chemie (International ed. in English) · 2025
    Review
  7. HPLC-Based Automated Synthesis and Purification of Carbohydrates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. HPLC-Based Automated Synthesis of Glycans in Solution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  13. Automated Solid Phase Assisted Synthesis of a Heparan Sulfate Disaccharide Library.Organic chemistry frontiers : an international journal of organic chemistry · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Enzymatic Building-Block Synthesis for Solid-Phase Automated Glycan Assembly.Angewandte Chemie (International ed. in English) · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matteo PanzaDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. demchenkoa@umsl.edu.
Keith J StineDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. demchenkoa@umsl.edu.
Alexei V DemchenkoDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. demchenkoa@umsl.edu.ORCID http://orcid.org/0000-0003-3515-212X

Funding

Automation of the chemical synthesis of human milk oligosaccharidesR01GM111835 · NIGMS · SAINT LOUIS UNIVERSITY · PI DEMCHENKO, ALEXEI V · 2014 to 2023
$2.5M
Refinement and implementation of the automated oligosaccharide synthesizerU01GM120673 · NIGMS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI DE MEO, CRISTINA, DEMCHENKO, ALEXEI V · 2016 to 2019
$2.2M
NIGMS NIH HHS R01 GM111835NIGMS NIH HHS U01 GM120673
6 · The paper itself

Abstract

Reported herein is the development of a user-friendly platform for simple and transformative automation based on standard HPLC equipment. We showcase how the improved platform works in application to the completely automated, a "press of the button," synthesis of various glycan sequences.

Identifiers

PMID31930269
PMCPMC7656230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.