Evidence map›Paper›PMID 31930189›Full record

ArticleACS applied bio materials2019

Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions.

Jeanne E Lemaster, Ananthakrishnan Soundaram Jeevarathinam, Ajay Kumar, Bhargavi Chandrasekar, Fang Chen, Jesse V Jokerst

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jeanne E LemasterDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Ananthakrishnan Soundaram JeevarathinamDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Ajay KumarDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Bhargavi ChandrasekarDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Fang ChenDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0002-6675-5508
Jesse V JokerstDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0003-2829-6408
University of California San Diego · US

Funding

Therapeutic Drug Monitoring with a Wearable Ultrasound-based SensorDP2HL137187 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2016 to 2019
$2.7M
Cancer Researchers in Nanotechnology (CRIN)T32CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, ZHANG, DONG-ER · 2017 to 2021
$994k
A Therapeutic Tool for Ultrasound-Guided Stem Cell TherapyR00HL117048 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2015 to 2017
$747k
Vevo LAZR Photoacoustic Imaging SystemS10OD021821 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2016 to 2016
$594k
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
MANTA ViewSizer 3011 Nanoparticle Characterization SystemS10OD023555 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2018 to 2018
$137k
NCI NIH HHS T32 CA153915NHLBI NIH HHS DP2 HL137187NHLBI NIH HHS R00 HL117048NIH HHS S10 OD021821NIH HHS S10 OD023527NIH HHS S10 OD023555
6 · The paper itself

Abstract

Synthetic melanin nanoparticles have value in metal chelation, photoprotection, and biocompatibility. Applications of these materials have been reported in optics, biomedicine, and electronics. However, precise size control has remained relatively difficult-especially for materials below 1000 nm. In this paper we describe the synthesis of ultrasmall synthetic nanoparticles with size of 9.4-31.4 nm in weakly acidic and neutral conditions via UV-irradiation. Size control of these particles was possible by varying the pH from 6.4-10.0. We then used UV-vis, FTIR, and nuclear magnetic resonance to investigate the mechanism of UV-induced polymerization. The data show that reactive oxygen species from UV irradiation oxidizes intermediates of the reaction and accelerates the formation of these synthetic melanin structures.

Indexed as

facile preparationmechanismmelaninpolydopaminesynthesissynthetic melanin nanoparticlesUV irradiation

Identifiers

PMID31930189
PMCPMC6953903
OpenAlexW2975630136

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.