ArticlePorto biomedical journal
Hypocalcemia in cancer patients: An exploratory study.
Article in Porto biomedical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Assessment of metal exposure in fingernails of patients with nasopharyngeal cancer: a case study in Vietnamese men.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Case report of severe hypocalcemia with atypical symptoms after zoledronic acid in palliative care: a deprescribing pitfall.BMC palliative care · 2026Article
- Biochemical and haemostatic variables associated with metastasis in dogs with carcinoma or sarcoma.The Journal of small animal practice · 2026Article
- Metabolic Signatures in Lung Cancer: Prognostic Value of Acid-Base Disruptions and Serum Indices.International journal of molecular sciences · 2025Article
- Refractory Denosumab-induced Hypocalcemia in a High-risk Patient With Osteoblastic Metastatic Prostate Adenocarcinoma.JCEM case reports · 2025Article
- Low serum creatinine as well as high serum creatinine is associated with prognosis of patients with cancer in end-of-life.Korean journal of family medicine · 2025Article
- Recurrent severe hypocalcemia following chemotherapy regimen changes in advanced breast cancer: two case reports.Journal of medical case reports · 2024Article
- The Generation of a Lung Cancer Health Factor Distribution Using Patient Graphs Constructed From Electronic Medical Records: Retrospective Study.Journal of medical Internet research · 2022Article
- Sensory neuron dysfunction in orthotopic mouse models of colon cancer.Journal of neuroinflammation · 2022Article
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- Preoperative Low Serum Calcium Levels Predict Poor Prognosis for Patients with Esophageal Cancer.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2022Article
- Analyzing the drivers of cancer relapse: hypocalcemia and iron absorption in hormone-dependent female cancers.American journal of translational research · 2022Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCalcium has several physiological functions and when it registers abnormal serum levels those functions may be impacted with potentially severe consequences. There is much research on hypercalcemia in cancer patients, but there are no recent studies on the prevalence of hypocalcemia in those patients. However, there has been an evolution in oncology, namely, new drugs that may directly or indirectly result in hypocalcemia. The primary aim was to explore the association of hypocalcemia with the diverse types of cancer. The secondary aim was to study the influence that hypocalcemia might have on survival.
methodsReview of the records of patients ≥18 years old, with total calcium <2.0 mmol/L measured in 2013 in a cancer center.
resultsEight hundred twenty-nine patients were included. Four hundred thirty-nine (53%) were male. The median age was 63 years. The most frequent cancer diagnoses were hematological 196 (24%) and colorectal 111 (13%). Six hundred thirty-eight patients had measured serum albumin, with a median of 25.5 g/L (14-47). When corrected for albumin level, calcium was in the normal range in 210 (33%) cases. The median survival of patients with corrected calcium lower than normal was 479 days (95% confidence interval [CI]: 309-649) and that of patients with normal corrected calcium was 62 days (95% CI: 33-91),
conclusionHypocalcemia is associated with several types of cancer. A low calcium level is not by itself a factor of a poor prognosis since other factors seem to be more important.
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