ReviewPorto biomedical journal
The electronic nose technology in clinical diagnosis: A systematic review.
Review in Porto biomedical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- A comprehensive meta-analysis and systematic review of breath analysis in detection of COVID-19 through Volatile organic compounds.Diagnostic microbiology and infectious disease · 2024Pooled it
- Diagnostic Performance of Electronic Noses in Cancer Diagnoses Using Exhaled Breath: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- The potential of volatile organic compounds-based breath analysis for COVID-19 screening: a systematic review & meta-analysis.Diagnostic microbiology and infectious disease · 2022Pooled it
- Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review.Pediatric research · 2021Pooled it
- Accuracy of a new electronic nose for prostate cancer diagnosis in urine samples.International journal of urology : official journal of the Japanese Urological Association · 2022Trial
- Olfactory Science and Technology in Prostate Cancer Diagnosis: From Invertebrate Models to Artificial Intelligence.Life (Basel, Switzerland) · 2026Review
- Electronic nose technology in bronchial asthma diagnosis and management.Multidisciplinary respiratory medicine · 2026Article
- Systematic process optimization for enhanced biosynthesis of 2-phenylethanol using Candida sorboxylosa.Bioprocess and biosystems engineering · 2026Article
- Urinary Metabolome Study for Monitoring Prostate Cancer Recurrence Following Radical Prostatectomy.Cancers · 2025Article
- Colorectal Cancer Detection Through Sweat Volatilome Using an Electronic Nose System and GC-MS Analysis.Cancers · 2025Article
- Breath fingerprint of colorectal cancer patients by gas chromatography-mass spectrometry analysis preparatory to e-nose analyses.Practical laboratory medicine · 2025Article
- Development of an E-Nose System for the Early Diagnosis of Sepsis During Mechanical Ventilation: A Porcine Feasibility Study.Sensors (Basel, Switzerland) · 2025Article
- Novel immune checkpoint inhibitor strategies in advanced non-small cell lung cancer: towards biomarker-driven therapies?Translational lung cancer research · 2025Article
- MORE-Q, a dataset for molecular olfactorial receptor engineering by quantum mechanics.Scientific data · 2025Article
- First Step on the Way to Identify Dermatophytes Using Odour Fingerprints.Mycopathologia · 2025Article
- Research hotspots and frontiers of application of mass spectrometry breath test in respiratory diseases.Frontiers in medicine · 2025Review
- High-speed odor sensing using miniaturized electronic nose.Science advances · 2024Article
- Quality characterization of tobacco flavor and tobacco leaf position identification based on homemade electronic nose.Scientific reports · 2024Article
- Analysis and application of volatile metabolic profiles ofRSC advances · 2024Article
- The Potential of Fecal Volatile Organic Compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm Infants: A Narrative Review.Sensors (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVolatile organic compounds (VOC) are end products of human metabolism (normal and disease-associated) that can be mainly excreted in breath, urine, and feces. Therefore, VOC can be very useful as markers of diseases and helpful for clinicians since its sampling is noninvasive, inexpensive, and painless. Electronic noses, or eNoses, provide an easy and inexpensive way to analyze gas samples. Thus, this device may be used for diagnosis, monitoring or phenotyping diseases according to specific breathprints (breath profile).
objectiveIn this review, we summarize data showing the ability of eNose to be used as a noninvasive tool to improve diagnosis in clinical settings.
methodsA PRISMA-oriented search was performed in PubMed and Cochrane Library. Only studies performed in humans and published since 2000 were included.
resultsA total of 48 original articles, 21 reviews, and 7 other documents were eligible and fully analyzed. The quality assessment of the selected studies was conducted according to the Standards for Reporting of Diagnostic Accuracy. Airway obstructive diseases were the most studied and Cyranose 320 was the most used eNose.
conclusionsSeveral case-control studies were performed to test this technology in diverse fields. More than a half of the selected studies showed good accuracy. However, there are some limitations regarding sampling methodology, analysis, reproducibility, and external validation that need to be standardized. Additionally, it is urgent to test this technology in intend-to-treat populations. Thus, it is possible to think in the contribution of VOC analysis by eNoses in a clinical setting.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.