ReviewJournal of immunology research2019
A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction.
Review in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Heparin-binding protein aggravates sepsis-induced acute lung injury by inhibiting the PERK-Nrf2-HO-1 signaling pathway.Journal of molecular histology · 2026Article
- CSF Leukocytes in Intracranial Infections: Diagnostic, Mechanistic, and Therapeutic Insights for Neurocritical Care.Cellular and molecular neurobiology · 2026Review
- Heparin-binding protein as an emerging host-response biomarker for periprosthetic joint infection: a narrative review.Frontiers in cellular and infection microbiology · 2026Review
- Biomarkers for Pediatric Acute Respiratory Distress Syndrome: A Systematic Review.Journal of inflammation research · 2026Review
- Heparin Binding Protein in Sepsis-A Comprehensive Overview of Pathophysiology, Clinical Usage and Utility as Biomarker.Biomedicines · 2025Review
- Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65.Cell biology and toxicology · 2025Article
- The accuracy of heparin-binding protein and interleukin-6 in predicting prognosis of severe pneumonia with sepsis patients.Frontiers in cellular and infection microbiology · 2025Article
- Pathogen Resistance and Biomarker-Based Diagnosis of Postoperative Urinary Tract Infections in Kidney Stone Patients.Infection and drug resistance · 2025Article
- Enhancing sepsis management: the role of dynamic heparin-binding protein monitoring in elderly patients.Frontiers in medicine · 2025Article
- Can We Improve Mortality Prediction in Patients with Sepsis in the Emergency Department?Medicina (Kaunas, Lithuania) · 2024Observational
- Long non‑coding RNAs MALAT1, NEAT1 and DSCR4 can be serum biomarkers in predicting urosepsis occurrence and reflect disease severity.Experimental and therapeutic medicine · 2024Article
- Article
- Heparin-Binding Protein Promotes Acute Lung Injury in Sepsis Mice by Blocking the Aryl Hydrocarbon Receptor Signaling Pathway.Journal of inflammation research · 2024Article
- The potential role of heparin-binding protein in neonatal sepsis: research progress.Frontiers in cellular and infection microbiology · 2024Review
- Heparin Binding Protein in Early Differential Diagnosis of Bacterial Meningitis.Indian journal of clinical biochemistry : IJCB · 2024Article
- A First Computational Frame for Recognizing Heparin-Binding Protein.Diagnostics (Basel, Switzerland) · 2023Article
- Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review.Molecules (Basel, Switzerland) · 2023Review
- Reference Interval for the Axis-Shield Clinical Chemistry Heparin-Binding Protein Assay.Diagnostics (Basel, Switzerland) · 2022Article
- Heparin-Binding Protein (HBP), Neutrophil Gelatinase-Associated Lipocalin (NGAL) and S100 Calcium-Binding Protein B (S100B) Can Confirm Bacterial Meningitis and Inform Adequate Antibiotic Treatment.Antibiotics (Basel, Switzerland) · 2022Article
- Heparin-Binding Protein Aggravates Acute Lung Injury in Septic Rats by Promoting Macrophage M1 Polarization and NF-Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. The biosynthetic HBP in neutrophils is rapidly released under the stimulation of bacteria, resulting in increased vascular permeability and edema. It is reasonable to speculate that the HBP in plasma may serve as a novel diagnostic marker for sepsis, bacterial skin infection, acute bacterial meningitis, leptospirosis, protozoan parasites, and even some noncommunicable diseases. It implies that in the detection and diagnosis of sepsis, it will be possible to make relevant diagnosis through this new indicator in the future. In this review, we summarize the typical biological function of HBP and its latest research progress to provide theoretical basis for clinical prediction and diagnosis of sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.