Evidence map›Paper›PMID 31930146›Full record

ReviewJournal of immunology research2019

Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis.

Hui Fan, Aiyun Wang, Yuan Wang, Ye Sun, Jing Han, Wenxing Chen, Shijun Wang, Yuanyuan Wu, Yin Lu

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. The Gut in Critical Illness.Current gastroenterology reports · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Gut microbiota in insulin resistance: a bibliometric analysis.Journal of diabetes and metabolic disorders · 2024
    Review
  10. HumanTissue barriers · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Roles of microRNAs in inflammatory bowel disease.International journal of biological sciences · 2021
    Review
  19. Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies.Frontiers in cellular and infection microbiology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hui FanJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Aiyun WangJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0002-4745-7302
Yuan WangJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Ye SunJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Jing HanJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Wenxing ChenJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Shijun WangShandong Co-Innovation Center of TCM Formula, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong 250035, China.
Yuanyuan WuJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0001-6231-2315
Yin LuJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0003-2063-8485
Nanjing University of Chinese Medicine · CNShandong University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate lymphoid cells (ILCs), identified in the early years of this century as a new class of leukocyte family unlike the B or T lymphocytes, play a unique role bridging the innate and adaptive immune responses in mucosal immunity. Their origin, differentiation, and activation process and functions have caught global interest. Recently, accumulating evidence supports that ILCs are vital regulators for gastrointestinal mucosal homeostasis through interactions with other structural and stromal cells in gut epithelial barriers. This review will explore the functions of ILCs and other cells in maintaining gut homeostasis and feature the crosstalk between ILCs with other cells and potential pharmacotherapy targeting ILCs applicable in intestinal innate immunity.

Indexed as

AnimalsCell DifferentiationCytokinesDendritic CellsHomeostasisHumansImmunity, InnateImmunity, MucosalIntestinal MucosaLymphocytesMacrophagesT-LymphocytesCytokines

Identifiers

PMID31930146
PMCPMC6942837
OpenAlexW2995992837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.