ArticleAnnals of translational medicine2019
Sleep apnea and risk of traumatic brain injury and associated mortality and healthcare costs: a population-based cohort study.
Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Work Productivity Burden Among Patients With Obstructive Sleep Apnea and Obesity Versus Controls Without Obstructive Sleep Apnea or Obesity.Journal of occupational and environmental medicine · 2026Article
- Patient Perspectives of a Sleep Apnea Treatment Adherence Intervention Adapted for Persons with Traumatic Brain Injury.Brain injury · 2025Article
- Obstructive sleep apnea and polysomnographic predictors of neuropsychological performance two years after injury in a prospective cohort of adults with traumatic brain injury.The Clinical neuropsychologist · 2025Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
- Effect of Obstructive Sleep Apnea on Outcomes After Traumatic Brain Injury: A Retrospective Cohort Analysis.Neurocritical care · 2022Article
- Association between Parkinson's disease and proton pump inhibitors therapy in older people.BioMedicine · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was aimed to investigate whether sleep apnea patients had a higher risk of traumatic brain injury.
methodsData were collected from the Taiwan Longitudinal Health Insurance Database during the period of 2000-2012. The study cohort comprised 6,456 patients aged ≥20 years with a first diagnosis of sleep apnea. The primary outcome was the incidence of traumatic brain injury. Kaplan-Meier survival analysis and Cox proportional-hazards modeling were used.
resultsAfter adjustments for associated comorbidities and hypnotic medications, sleep apnea patients were associated with a 1.19-fold higher risk of traumatic brain injury (95% CI, 1.07-1.33) compared with patients without sleep apnea. Sleep apnea patients who took benzodiazepine (BZD) had a 1.30-fold increased risk of traumatic brain injury compared with patients without sleep apnea (95% CI, 1.14-1.49). However, this risk was not statistically significant, with a 1.03-fold risk of traumatic brain injury in sleep apnea patients without BZD use (95% CI, 0.84-1.25) compared with patients without sleep apnea. Compared with patients without sleep apnea, the risk of traumatic brain injury in sleep apnea patients aged 65-79 years old was higher (adjusted hazard ratio, 1.36; 95% CI, 1.06-1.74).
conclusionsSleep apnea patients, regardless of hypnotic use, had a higher risk of traumatic brain injury compared with patients without sleep apnea.
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