ArticleAnnals of translational medicine2019
Whole-brain morphometric studies in alcohol addicts by voxel-based morphometry.
Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis.Psychopharmacology · 2021Pooled it
- Aberrant regional homogeneity in multiple frequency bands in patients with alcohol use disorder.Frontiers in psychiatry · 2025Article
- Altered individual gray matter structural covariance networks in early abstinence patients with alcohol dependence.Brain imaging and behavior · 2024Article
- Examination of reward processing dysfunctions in the left dorsal striatum and other brain regions among psychiatric inpatients with substance use.Drug and alcohol dependence · 2024Article
- Effects of current alcohol use on brain volume among older adults in the Gothenburg H70 Birth Cohort study 2014-16.European archives of psychiatry and clinical neuroscience · 2024Article
- Investigation of Gray Matter Changes Using Voxel-Based Morphometry in HIV-Negative Patients with General Paresis of the Insane.Neuropsychiatric disease and treatment · 2024Article
- Effect of alcohol, tobacco, and cannabis co-use on gray matter volume in heavy drinkers.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Article
- Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the morphological changes of the whole-brain in patients with alcohol addiction using voxel-based morphometry (VBM).
methodsTwenty alcohol addiction individuals and 20 healthy control volunteers, matched in gender, age, handedness and education, were enrolled as the alcohol addiction group and control group, respectively, from June 2017 to February 2018. The two groups underwent magnetic resonance imaging (MRI) scans of the whole-brain using a 3.0T MRI system, and the MRI images were analyzed by VBM. Total brain volume analysis was performed to observe the changes of local brain volume. Independent samples
resultsGray matter volume (GMV) was significantly more reduced in the left middle frontal gyrus, left superior frontal gyrus, left precuneate gyrus, left gyrus rectus, right medial superior frontal gyrus, and right orbital gyrus in patients with alcohol addiction than in healthy controls. White matter volume (WMV) in the bilateral superior frontal gyrus was also significantly more reduced in patients with alcohol addiction than in healthy controls. Whole-brain VBM results showed that white matter and brain parenchyma volumes (BPVs) were significantly smaller in patients with alcohol addiction than in healthy controls (both P<0.05). There was no significant difference in GMV between patients with alcohol addiction and healthy controls (P>0.05).
conclusionsThere are dominant areas of brain atrophy in patients with alcohol addiction. The VBM has a potential application value in detecting subtle brain atrophy in patients with alcohol addiction and providing an imaging basis in the diagnosis of alcohol addiction.
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