ArticleCurrent addiction reports2019
The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.
Article in Current addiction reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Associations of polygenic risk scores for smoking heaviness and lifetime cannabis use with tobacco and cannabis co-use trajectories among African Americans.Drug and alcohol dependence · 2023Article
- Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies.Brain research bulletin · 2022Review
- Multi-type childhood maltreatment exposure and substance use development from adolescence to early adulthood: A GxE study.Child abuse & neglect · 2022Article
- [Comorbidity of posttraumatic stress disorder and addiction from a biopsychosocial perspective].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2022Article
- Effects of OPRM1 and DRD2 on brain structure in drug-naïve adolescents: Genetic and neural vulnerabilities to substance use.Psychopharmacology · 2022Article
- Understanding the Etiology of Adolescent Substance Use through Developmental Perspectives.Child development perspectives · 2021Article
- Mental health and music engagement: review, framework, and guidelines for future studies.Translational psychiatry · 2021Review
- A review of psychosocial factors linked to adolescent substance use.Pharmacology, biochemistry, and behavior · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThis review discusses the importance of understanding the impact of genetic factors on adolescent substance use within a developmental framework. Methods for identifying genetic factors, relevant endophenotypes and intermediate phenotypes, and gene-environment interplay effects will be reviewed.
findingsPrior work supports the role of polygenic variation on adolescent substance use. Mechanisms through which genes impact adolescent phenotypes consist of differences in neural structure and function, early temperamental differences, and problem behavior. Gene-environment interactions are characterized by increased vulnerability to both maladaptive and adaptive contexts. SUMMARY: Developmental considerations in genetic investigations highlight the critical role that polygenic variation has on adolescent substance use. Yet, determining what to do with this information, especially in terms of personalized medicine, poses ethical and logistic challenges.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.