ArticleAdvances in orthopedics2019
The Impact of Preoperative Opioid Use Disorder on Complications and Costs following Primary Total Hip and Knee Arthroplasty.
Article in Advances in orthopedics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Factors Associated With Surgical Site Infections in Adults Following a Replacement of Weight-Bearing Joints: A Systematic Review.International wound journal · 2026Pooled it
- Tibial tubercle to trochlear groove distance versus tibial tubercle to posterior cruciate ligament distance for predicting patellar instability: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Meta-analysis of retrospective studies suggests that the pre-operative opioid use is associated with an increased risk of adverse outcomes in total hip and or knee arthroplasty.International orthopaedics · 2021Pooled it
- Article
- Outcomes following arthroscopic rotator cuff repair adversely affected by underlying diagnosis of glenohumeral osteoarthritis: a matched cohort analysis.JSES reviews, reports, and techniques · 2026Article
- Treatment gaps for opioid use disorder among commercially insured US surgical patients, 2016-2022.Regional anesthesia and pain medicine · 2026Article
- Narrative review: Managing buprenorphine and opioid use disorder in the perioperative setting.Pain practice : the official journal of World Institute of Pain · 2025Review
- Projections and Epidemiology of Revision Hip and Knee Arthroplasty in the United States to 2040-2060.Arthroplasty today · 2023Article
- Impact of preexisting opioid dependence on morbidity, length of stay, and inpatient cost of urological oncological surgery.World journal of urology · 2023Article
- Rates and Outcomes of Periprosthetic Joint Infection in Persons Who Inject Drugs.The Journal of arthroplasty · 2023Article
- Chronic opioid use after joint replacement surgery in seniors is associated with increased healthcare utilization and costs: a historical cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Article
- Association of Preoperative Opioid Use With Complication Rates and Resource Use in Patients Undergoing Hip Arthroscopy for Femoroacetabular Impingement.Orthopaedic journal of sports medicine · 2021Article
- Exploration of Overdose Risk Score and Postoperative Complications and Health Care Use After Total Knee Arthroplasty.JAMA network open · 2021Article
- Patient Perceptions of COVID-19-Related Surgical Delay: An Analysis of Patients Awaiting Total Hip and Knee Arthroplasty.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2020Article
- It is not 'business as usual' for orthopaedic surgeons in May 2020- the Austrian-German-Swiss experience.Journal of experimental orthopaedics · 2020Review
- Opioid Use Disorder Is Associated with an Increased Risk of Infection after Total Joint Arthroplasty: A Large Database Study.Clinical orthopaedics and related research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionMultiple studies have demonstrated that patients taking opioids in the preoperative period are at elevated risk for complications following total hip (THA) and knee (TKA) arthroplasty. However, the incidence and impact of opioid use disorder (OUD) among these patients-both clinically and fiscally-remain unknown. The purpose of this study was to investigate this relationship.
methodsThe Nationwide Readmission Database (NRD) was used to identify patients undergoing THA and TKA from 2011 to 2015. Coarsened exact matching was used to statistically match the OUD and non-OUD cohorts. Further analysis was then conducted on matched cohorts with multivariate analysis. The incidence of OUD was also determined, and the costs associated with this comorbidity were calculated.
resultsThe incidence of OUD in arthroplasty patients increased 80% over the study period. OUD patients had higher odds of prosthetic joint infection (OR 1.55, 95% CI 1.23-1.94), wound complication (OR 1.40, 95% CI 1.12-1.76), prosthetic complication (OR 1.37, 95% CI 1.10-1.70), and revision surgery (OR 1.47, 95% CI 1.19-1.81). OUD patients also had longer length of stays (TKA: +0.67 days; THA: +1.09 days), higher readmission (OR 1.60, 95% CI 1.43-1.79), and increased 90-day costs (TKA: +$3,602 [95% CI $3,138-4,065]; THA: +4,527 [95% CI $3,593-4,920).
conclusionOpioid use disorder is becoming a more common comorbidity among THA and TKA patients. This is concerning as it represents a significant risk factor for postoperative complication. It additionally confers increased perioperative costs. Patients with OUD should be counseled on their elevated risk, and future work will be needed to determine if this is a modifiable risk factor.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.