Evidence map›Paper›PMID 31929856›Full record

ArticleOxidative medicine and cellular longevity2019

The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk.

A Magenta, M D'Agostino, S Sileno, L Di Vito, C Uras, D Abeni, F Martino, F Barillà, S Madonna, C Albanesi and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

A MagentaExperimental Immunology Laboratory, IDI-IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-9054-337X
M D'AgostinoExperimental Immunology Laboratory, IDI-IRCCS, Rome, Italy.
S SilenoExperimental Immunology Laboratory, IDI-IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-2036-2071
L Di VitoUnit of Cardiology, IDI-IRCCS, Rome, Italy.
C UrasUnit of Cardiology, IDI-IRCCS, Rome, Italy.
D AbeniClinical Epidemiology Unit, IDI-IRCCS, Rome, Italy.
F MartinoDepartment of Pediatrics, Sapienza University of Rome, Italy.
F BarillàDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, Italy.
S MadonnaExperimental Immunology Laboratory, IDI-IRCCS, Rome, Italy.
C AlbanesiExperimental Immunology Laboratory, IDI-IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-7537-6833
M NapolitanoClinical Epidemiology Unit, IDI-IRCCS, Rome, Italy.
M C CapogrossiDivision of Cardiology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
G MelilloUnit of Cardiology, IDI-IRCCS, Rome, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITSapienza University of Rome · ITNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory skin disease associated with reactive oxygen species (ROS) increase and a higher risk of cardiovascular (CV) events. We previously showed that the miR-200 family (miR-200s) is induced by ROS, miR-200c being the most upregulated member responsible for apoptosis, senescence, ROS increase, and nitric oxide decrease, finally causing endothelial dysfunction. Moreover, circulating miR-200c increases in familial hypercholesterolemic children and in plaques and plasma of atherosclerotic patients, two pathologies associated with increased ROS. Given miR-200s' role in endothelial dysfunction, ROS, and inflammation, we hypothesized that miR-200s were modulated in lesional skin (LS) and plasma of psoriatic patients (Pso) and that their levels correlated with some CV risk determinants at a subclinical level. All Pso had severe psoriasis, i.e., Psoriasis Area and Severity Index (PASI) > 10, and one of the following: at least two systemic psoriasis treatments, age at onset < 40 years, and disease duration > 10 years. RNA was extracted from plasma (Pso,

Indexed as

BiomarkersCardiovascular DiseasesDisease ProgressionEndothelium, VascularFemaleHumansMaleMicroRNAsMiddle AgedOxidative StressPsoriasisReactive Oxygen SpeciesRiskSeverity of Illness IndexSkinUp-RegulationBiomarkersMicroRNAsMIRN200 microRNA, humanReactive Oxygen Species

Identifiers

PMID31929856
PMCPMC6939435
OpenAlexW2994848918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.