ReviewEvidence-based complementary and alternative medicine : eCAM2019
Hepatoprotective Activity of Some Medicinal Plants in Sudan.
Review in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Liver Disease and Plant-Derived Phytoconstituents: From Ethnopharmacology to Modern Medicine.Phytotherapy research : PTR · 2026Review
- Antioxidant efficacy ofAvicenna journal of phytomedicine · 2026Article
- Hepatoprotective Potential of Indian Medicinal Plants.Combinatorial chemistry & high throughput screening · 2026Review
- Antioxidant and protective effects of methanolicOpen veterinary journal · 2025Article
- Hepatoprotective Potential ofCurrent drug discovery technologies · 2025Review
- An In-depth Review onAnti-cancer agents in medicinal chemistry · 2025Review
- Review
- Evaluation of the Hepatoprotective Properties of Traditional Formulations Based onAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats.Saudi journal of biological sciences · 2023Article
- Involvement of PI3K/HIF-1α/c-MYC/iNOS Pathway in the Anticancer Effect ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Ethanolic Extract fromPharmaceuticals (Basel, Switzerland) · 2023Article
- Capsaicin protects against septic acute liver injury by attenuation of apoptosis and mitochondrial dysfunction.Heliyon · 2023Article
- Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety.Advances in pharmacological and pharmaceutical sciences · 2023Review
- Hepatoprotective effect of nanoniosome loaded Myristica fragrans phenolic compounds in mice-induced hepatotoxicity.Journal of cellular and molecular medicine · 2022Article
- Phytochemical Characterization of Water Avens (Plants (Basel, Switzerland) · 2022Article
- Sinapic acid ameliorates paracetamol-induced acute liver injury through targeting oxidative stress and inflammation.Molecular biology reports · 2022Article
- Chemico-Pharmacological Screening of the Methanol Extract ofMolecules (Basel, Switzerland) · 2022Article
- Article
- Hepatoprotective effect of Trigonella foenum graecum against ethanol-induced cell death in human liver cells (HepG2 and Huh7).Molecular biology reports · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver disorders are common in Sudan and elsewhere. These are traditionally treated by medicinal plants especially in rural areas where they are widely available.
methodsThis review was based on scientific research in hepatoprotective plants performed in Sudan for the period between 2001 and 2016 AD. Data collection was done through scientific evidence of local and international published data, theses, and publications from some libraries in Sudanese universities. Internet was also used to collect published data in different international scientific journals.
resultsIn this study, 21 plants from different families were reviewed for the hepatoprotective activity in Sudan. These plants are widely used in traditional medicine for their availability and cheap prices. All of these plants have been scientifically investigated through experimental animal models which confirmed their hepatoprotective activities. This was evaluated by measuring several parameters including liver markers (AST, ALT, ALP, total protein, albumin, and bilirubin) and histopathological investigation. Nineteen (90.5%) of the herbal plants were found to possess significant hepatoprotective activity in animal models. Two (9.5%) of the plants were devoid of this activity. The action of these plants is largely attributed to their phytoconstituents such as flavonoids, antioxidant, and anti-inflammatory effects.
conclusionSudanese herbs may offer novel alternatives to treat liver disorders. Yet determination of the active principle responsible for hepatoprotection needs to be investigated. Further studies on these plants are necessary to establish the efficacy, safety, and exact mechanism of action as a moral alternative in the treatment of liver disorders.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.