ReviewInternational journal of endocrinology2019
Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review.
Review in International journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Are there atypical sites of IgG4 related disease in head and neck region? Personal experience and literature review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Review
- Immunoglobulin G4-related Autoimmune Pancreatitis and Hypopituitarism Following Immune Checkpoint Inhibitor Therapy.Internal medicine (Tokyo, Japan) · 2025Article
- Prolactin deficiency in the context of other pituitary hormone abnormalities : Special issue: hypoprolactinemia: a neglected endocrine disorder.Reviews in endocrine & metabolic disorders · 2024Review
- Mikulicz's disease combined with IgG4-related hypophysitis: a case report.BMC geriatrics · 2024Article
- IgG4-related hypophysitis: a retrospective cohort study.Acta neurochirurgica · 2022Article
- Typing of inflammatory lesions of the pituitary.Pituitary · 2022Article
- IgG4-related hypophysitis: A monocentric experience from North India.Surgical neurology international · 2022Article
- Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.The Journal of clinical endocrinology and metabolism · 2022Review
- Increased Serum-Immunoglobulin G4 Levels in a 12-Year-Old Male Patient With Central Diabetes Insipidus.Cureus · 2021Article
- Deterioration of pituitary function without relapse after steroid therapy for IgG4-related hypophysitis.Endocrinology, diabetes & metabolism case reports · 2021Article
- IgG4-Related Inflammatory Pseudotumor Involving the Clivus: A Case Report and Literature Review.Frontiers in endocrinology · 2021Review
- IgG4-Related Disease: Endocrine Involvement, Clinical Implications, and Management Strategies.Discoveries (Craiova, Romania)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIgG4-related hypophysitis (IgG4-RH) is a rare disease, and its prevalence remains unclear. In recent years, an increasing number of cases have been reported because of the increasing recognition of this disease. We aimed to summarize case reports of IgG4-RH and outline the clinical features and outcomes.
methodsWe performed PubMed search of articles using the search terms "hypophysitis [AND] IgG4." Consequently, only 54 English articles (76 cases) met Leporati's diagnostic criteria.
resultsOf the 76 cases, the ratio of men to women was 1.5 : 1, and the age at diagnosis was 54.1 ± 17.8 years. The median IgG4 concentration was 405.0 mg/dl. Anterior hypopituitarism, isolated central diabetes insipidus, and panhypopituitarism were observed in 14 (18.4%), 12 (15.8%), and 44 (57.9%) cases, respectively. The sequence of anterior hormone deficiency was as follows: gonadotropin (68.4%), ACTH (63.2%), TSH (59.2%), GH (48.7%), and prolactin (42.1%). The median number of involved organs was 1.5, and the lung (18.4%), retroperitoneum (17.1%), kidney (15.8%), submandibular glands (14.5%), and pancreas (13.2%) were the common involved organs. Elevated IgG4 concentration and normal IgG4 level were in 42 (76.4%) and 13 (23.6%) cases, respectively. Patients with elevated serum IgG4 concentration were older (60.9 ± 14.3 vs 45.6 ± 17.4,
conclusionIn this review, we found that there were different characteristics between different genders. Patients with elevated serum IgG4 level in terms of some clinical features were also different from those with normal serum IgG4 level. However, the data in this review were limited by bias and confounding. Further clinical studies with larger sample sizes are warranted.
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Registered trials
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