Evidence map›Paper›PMID 31929738›Full record

ArticleInternational journal of medical sciences2020

Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury.

Yi-Ju Hsu, Chun-Shen Ho, Mon-Chien Lee, Chin-Shan Ho, Chi-Chang Huang, Nai-Wen Kan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
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  6. Article
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  8. CNanomedicine (London, England) · 2025
    Article
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  11. Article
  12. Article
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  17. Beta-hydroxy-beta-methylbutyrate associated with low-intensity exercise training improves skeletal muscle regeneration through the IGF-Akt pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
    Article
  18. Article
  19. Myricetin Suppresses Ovarian CancerFrontiers in oncology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yi-Ju HsuGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Chun-Shen HoGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Mon-Chien LeeGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Chin-Shan HoGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Chi-Chang HuangGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Nai-Wen KanCenter for General Education, Taipei Medical University, Taipei 11031, Taiwan.
National Taiwan Sport University · TWLuodong Poh-Ai Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle injuries frequently occur in contact sports events. The current treatment options for soft tissue injuries remain suboptimal and often result in delayed or incomplete recovery of damaged muscles. Resveratrol (RES) is a phenolic phytochemical, well-known for its antioxidant and anti-inflammatory properties. The purpose of this study is to evaluate the potential beneficial effects of RES supplementation on inflammation and regeneration in skeletal muscle after a contusion injury, in comparison to a conventional treatment of nonsteroidal anti-inflammatory drugs (NSAID). After one week of acclimation, forty eight -week-old male ICR mice were randomly divided into the five groups (n=8 per group): 1) normal control (NC), 2) mass-drop injury without any treatment (mass-drop injury, MDI), 3) post-injury NSAID treatment (MDI+ 10mg/kg NSAID), 4) post-injury RES supplementation (MDI+ 25mg/kg/day RES) and 5) post-injury treatment with RES and NSAID (MDI + resveratrol+ NSAID). After muscle contusion injury of the left gastrocnemius muscle, RES or NSAID were orally administered post-injury once a day for 7 days. Results showed that the MDI group had significantly higher serum uric acid (UA), CREA (creatinine), LDH (lactic dehydrogenase) and creatine kinase (CK) than the normal control group. Treatment with resveratrol reduced muscle damage as evidenced by the significantly decreased serum levels of UA, CREA, LDH and CK after contusion-induced muscle injuries in mice. In addition, RES and RES + NSAID groups promoted muscle satellite cell regeneration with increase in desmin protein after injury. Our results suggest that resveratrol combined with NSAID potentially improve muscle recovery and may be a potential candidate for further development as an effective clinical treatment for muscle repair.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsContusionsCreatine KinaseCreatinineDisease Models, AnimalHumansInflammationLactate DehydrogenasesMiceMuscle, SkeletalResveratrolSoft Tissue InjuriesUric AcidAnti-Inflammatory Agents, Non-SteroidalAntioxidantsCreatine KinaseCreatinineLactate DehydrogenasesResveratrolUric AcidCKLDHmass-drop injuryNSAIDregeneration

Identifiers

PMID31929738
PMCPMC6945554
OpenAlexW2997149127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.