ArticleProceedings of SPIE--the International Society for Optical Engineering2019
Noninvasive imaging of dual-agent uptake in glioma and normal tissue using MRI-coupled fluorescence tomography.
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Estimating paired-agent uptake in altered tumor vasculature using MRI-coupled fluorescence tomography.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Estimating drug delivery using hybrid system for simultaneous dynamic MRI and fluorescence tomography.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
As the role of immuno-oncological therapeutics expands, the capacity to noninvasively quantify molecular targets and drug-target engagement is increasingly critical to drug development efforts and treatment monitoring. Previously, we showed that MRI-coupled dual-agent fluorescence tomography (FMT) is capable of estimating the concentration of epidermal growth factor receptor (EGFR) in orthotopic glioma models noninvasively. This approach uses the dynamic information of two fluorescent agents (a targeted agent and untargeted isotype) to estimate tumor receptor concentration in vivo. This approach generally relies on the two tracers having similar kinetics in normal tissues, which may not always be the case. Herein, we describe an additional channel added to the MRI-FMT system which measures the uptake of both agents in the normal muscle, data which can be used to compensate for differing kinetic behavior.
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Registered trials
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