ArticlePloS one2020
Morphological and functional characteristics of mitral annular calcification and their relationship to stroke.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Caseous calcification of the mitral annulus as a rare cause of embolic stroke in a young patient with end-stage renal disease: a case report.European heart journal. Case reports · 2026Article
- Thrombus on Mitral Annular Calcification: A Systematic Review of Management and Outcomes.CJC open · 2024Review
- Rethinking Mitral Annular Calcification and Its Clinical Significance: From Passive Process to Active Pathology.Journal of personalized medicine · 2024Review
- 2023 Korean Society of Echocardiography position paper for the diagnosis and management of valvular heart disease, part II: mitral and tricuspid valve disease.Journal of cardiovascular imaging · 2024Review
- Article
- Multimodal Cardiac Imaging in the Assessment of Patients Who Have Suffered a Cardioembolic Stroke: A Review.Journal of cardiovascular development and disease · 2023Review
- Risk Factors and Outcomes With Progressive Mitral Annular Calcification.Journal of the American Heart Association · 2023Article
- Surgery for mitral annular caseous calcification-related calcified amorphous tumor: a case report.General thoracic and cardiovascular surgery cases · 2023Article
- Novel 3D Echocardiographic Technique for Mitral Calcium Mapping.Journal of clinical medicine · 2023Article
- Prognostic Implication of Mitral Valve Disease and Its Progression in East Asian Patients With Hypertrophic Cardiomyopathy.Journal of the American Heart Association · 2023Article
- Cardiac tumor in the left ventricular outflow tract: atypical presentation of calcified amorphous tumor.Journal of surgical case reports · 2022Article
- Risk of Stroke With Mitral Stenosis: The Underlying Mechanism, Treatment, and Prevention.Cureus · 2022Review
- Caseous calcification of mitral annulus in the setting of multivessel disease.Journal of geriatric cardiology : JGC · 2022Article
- Mitral and Aortic Regurgitation in Patients Undergoing Kidney Transplantation: The Natural Course and Factors Associated With Progression.Frontiers in cardiovascular medicine · 2022Article
- Sex Differences in Mitral Annular Calcification and the Clinical Implications.Frontiers in cardiovascular medicine · 2021Article
- Calcified amorphous tumor with caseous calcification of mitral annulus in hemodialysis patients.General thoracic and cardiovascular surgery · 2020Article
- Caseous mitral valve calcification and concurrent hypertrophic obstructive cardiomyopathy: A rare cause of stroke.International journal of cardiology. Heart & vasculature · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMitral annular calcification (MAC) is associated with risk of stroke. This study aimed to define the morphological and functional characteristics of MAC that are related to stroke.
methodsA total of 460 subjects with MAC from transthoracic echocardiography in a single center from 2012 to 2016 was retrospectively reviewed. Subjects were classified into two groups according to history of stroke [Group 1 (n = 366): without stroke; Group 2 (n = 94): with stroke]. Morphological and functional features of MAC on echocardiogram were scored from 0 to 3 according to MAC mobility, presence of echodense mass with central echolucencies in the periannular region suggesting caseous necrosis, and functional stenosis.
resultsSignificantly more patients in group 2 were men and had history of diabetes mellitus, dyslipidemia, atrial fibrillation, or infective endocarditis. Although MAC thickness and extent did not differ between the two groups, group 2 showed a considerably higher MAC score than group 1 (0.50 ± 0.77 vs. 0.23 ±0.52 p<0.001) as a result of the higher prevalence of each component in group 2 [mobility (22 vs. 11%, p = 0.003), echodense mass with central areas of echolucencies suggesting caseous necrosis (23 vs. 7%, p<0.001), and functional mitral stenosis (12 vs. 7%, p = 0.042)]. On logistic regression analysis, MAC score was independently associated with stroke and showed significant incremental value to demographic factors and comorbidities in association with stroke in a consecutive manner.
conclusionsIn conclusion, morphological and functional characteristics of MAC had incremental value in association with stroke over traditional risk factors. MAC score consisting of MAC mobility, typical echodense mass with central echolucencies suggesting caseous necrosis, and functional mitral stenosis was independently associated with stroke. MAC with high-risk features may act as a source of stroke or more potent composite surrogate markers for stroke-related risk factors.
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