ArticlePloS one2020
Characterization of dermal skin innervation in fibromyalgia syndrome.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pain in People With Fibromyalgia Syndrome (FMS) Undergoing or Following Surgery: A Systematic Narrative Review.Pain research & management · 2026Pooled it
- Evaluating skin biopsy findings in fibromyalgia: a systematic review.Reumatologia · 2026Review
- Aftersensations and Lingering Pain After Examination in Patients with Fibromyalgia Syndrome.Pain medicine (Malden, Mass.) · 2025Article
- The Human Superficial Fascia: A Narrative Review.International journal of molecular sciences · 2025Review
- Small fiber pathology in fibromyalgia syndrome.Pain reports · 2025Review
- Weathering the Pain: Ambient Temperature's Role in Chronic Pain Syndromes.Current pain and headache reports · 2025Review
- Vasodilatory Peripheral Response and Pain Levels following Radiofrequency Stressor Application in Women with Fibromyalgia.Biomedicines · 2024Article
- Quantifying innervation facilitated by deep learning in wound healing.Scientific reports · 2023Article
- Quantifying innervation facilitated by deep learning in wound healing.Research square · 2023Article
- Clinical criteria and diagnostic assessment of fibromyalgia: position statement of the Italian Society of Neurology-Neuropathic Pain Study Group.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Aftersensations and Lingering Pain After Examination in Patients with Fibromyalgia Syndrome.Pain medicine (Malden, Mass.) · 2022Article
- A Systematic Review and Meta-Analysis of the Prevalence of Small Fibre Impairment in Patients with Fibromyalgia.Diagnostics (Basel, Switzerland) · 2022Review
- Innervation of human superficial fascia.Frontiers in neuroanatomy · 2022Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology.
methodsSkin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene product 9.5, calcitonine gene-related peptide, substance P, CD31, and neurofilament 200 for small fiber subtypes. We assessed two skin sections per patient; on each skin section, two dermal areas (150 x 700 μm each) were investigated for dermal nerve fiber length (DNFL).
resultsIn FMS patients we found reduced DNFL of fibers with vessel contact compared to healthy controls (p<0.05). There were no differences for the other nerve fiber subtypes. DISCUSSION: We found less dermal nerve fibers in contact with blood vessels in FMS patients than in controls. The pathophysiological relevance of this finding is unclear, but we suggest the possibility of a relationship with impaired thermal tolerance commonly reported by FMS patients.
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