ArticlePLoS genetics2020
Dysfunction of Oskyddad causes Harlequin-type ichthyosis-like defects in Drosophila melanogaster.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 42 citations in OpenAlex.
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- Genomic functional annotation and comparative analysis of ABC transporter protein family genes in nine types of Chironomidae insects.BMC genomics · 2025Article
- Population Density Affects Drosophila Male Pheromones in Laboratory-Acclimated and Natural Lines.Journal of chemical ecology · 2024Article
- Natural Diversity of Cuticular Pheromones in a Local Population of Drosophila after Laboratory Acclimation.Insects · 2024Article
- Replenishment of Drosophila Male Pheromone After Mating.Journal of chemical ecology · 2024Article
- Genetic atlas of hygro-and thermosensory cells in the vinegar fly Drosophila melanogaster.Scientific reports · 2023Article
- ABCH2 transporter mediates deltamethrin uptake and toxicity in the malaria vector Anopheles coluzzii.PLoS pathogens · 2023Article
- Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila.Current biology : CB · 2022Article
- Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing.Genetics · 2022Article
- Aging-Related Variation of Cuticular Hydrocarbons in Wild Type and Variant Drosophila melanogaster.Journal of chemical ecology · 2022Article
- Toxicity of Dithiothreitol (DTT) toToxicology reports · 2021Article
- Glycosylhydrolase genes control respiratory tubes sizes and airway stability.Scientific reports · 2020Article
- Transcriptional Control of Quality Differences in the Lipid-Based Cuticle Barrier inFrontiers in genetics · 2020Article
- Form and function of the apical extracellular matrix: new insights fromFaculty reviews · 2020Review
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prevention of desiccation is a constant challenge for terrestrial organisms. Land insects have an extracellular coat, the cuticle, that plays a major role in protection against exaggerated water loss. Here, we report that the ABC transporter Oskyddad (Osy)-a human ABCA12 paralog-contributes to the waterproof barrier function of the cuticle in the fruit fly Drosophila melanogaster. We show that the reduction or elimination of Osy function provokes rapid desiccation. Osy is also involved in defining the inward barrier against xenobiotics penetration. Consistently, the amounts of cuticular hydrocarbons that are involved in cuticle impermeability decrease markedly when Osy activity is reduced. GFP-tagged Osy localises to membrane nano-protrusions within the cuticle, likely pore canals. This suggests that Osy is mediating the transport of cuticular hydrocarbons (CHC) through the pore canals to the cuticle surface. The envelope, which is the outermost cuticle layer constituting the main barrier, is unaffected in osy mutant larvae. This contrasts with the function of Snu, another ABC transporter needed for the construction of the cuticular inward and outward barriers, that nevertheless is implicated in CHC deposition. Hence, Osy and Snu have overlapping and independent roles to establish cuticular resistance against transpiration and xenobiotic penetration. The osy deficient phenotype parallels the phenotype of Harlequin ichthyosis caused by mutations in the human abca12 gene. Thus, it seems that the cellular and molecular mechanisms of lipid barrier assembly in the skin are conserved during evolution.
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