Evidence map›Paper›PMID 31929158›Full record

ReviewJournal of Alzheimer's disease : JAD2020

A Narrative Review of Handgrip Strength and Cognitive Functioning: Bringing a New Characteristic to Muscle Memory.

Keith A Shaughnessy, Kyle J Hackney, Brian C Clark, William J Kraemer, Donna J Terbizan, Ryan R Bailey, Ryan McGrath

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Keith A ShaughnessyDepartment of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA.
Kyle J HackneyDepartment of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA.
Brian C ClarkOhio Musculoskeletal and Neurological Institute, Ohio University, Athens, OH, USA.
William J KraemerDepartment of Human Sciences, The Ohio State University, Columbus, OH, USA.
Donna J TerbizanDepartment of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA.
Ryan R BaileyBrown School of Social Work, Washington University in St. Louis, St. Louis, MO, USA.
Ryan McGrathDepartment of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA.
North Dakota State University · USOhio University · USThe Ohio State University · USWashington University in St. Louis · US

Funding

WUSTL Transdisciplinary Pre- and Postdoctoral Training Program in Obesity and Cardiovascular DiseaseT32HL130357 · NHLBI · WASHINGTON UNIVERSITY · PI WILFLEY, DENISE ELLA · 2016 to 2025
$4.3M
Neural mechanisms of dynapeniaR01AG044424 · NIA · OHIO UNIVERSITY ATHENS · PI CLARK, BRIAN C · 2014 to 2018
$1.4M
NHLBI NIH HHS T32 HL130357NIA NIH HHS R01 AG044424
6 · The paper itself

Abstract

backgroundMeasures of handgrip strength have not only emerged as a clinically viable screening tool for determining risk for morbidity, functional disability, and early mortality, but also for helping to identify cognitive deficits. However, the phenomena that links low handgrip strength with cognitive decline remains unclear. The role of the muscular and neural systems, and their adaptations to muscle strengthening activities over the life course, may provide important information for how age-related changes to muscle mass, strength, and neural capacity influence cognition. Moreover, disentangling how handgrip strength and cognitive function are associated may help to inform healthcare providers working with aging adults and guide targeted interventions aiming to preserve muscle and cognitive functioning.

objectiveTo 1) highlight and summarize evidence examining the associations of handgrip strength and cognitive functioning, and 2) provide directions for future research in this area.

methodsArticles from the PubMed database were searched from November 2018-May 2019. The search term algorithm, inclusion and exclusion criteria were pre-specified by investigators.

resultsSeveral cross-sectional and longitudinal studies have revealed that measures of handgrip strength were associated with cognitive declines regardless of age demographics and the presence of comorbidities.

conclusionHandgrip strength can be used in clinical and epidemiological settings for helping to determine the onset and progression of cognitive impairment. Future research should continue to examine how handgrip strength and cognitive function are linked.

Indexed as

Alzheimer DiseaseCognitionCognitive DysfunctionHand StrengthHumansMemoryMuscle, SkeletalAgingAlzheimer’s diseasecognitiondementiamuscle weaknesssarcopenia

Identifiers

PMID31929158
PMCPMC7063546
OpenAlexW3000058179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.