Evidence map›Paper›PMID 31929146›Full record

ArticleClinical hemorheology and microcirculation2020

In vitro endothelial hyperpermeability occurs early following traumatic hemorrhagic shock.

Anoek L I van Leeuwen, David N Naumann, Nicole A M Dekker, Peter L Hordijk, Sam D Hutchings, Christa Boer, Charissa E van den Brom

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Article in Clinical hemorheology and microcirculation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The impact of hypertonic saline on damage control laparotomy after penetrating abdominal trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anoek L I van LeeuwenDepartment of Anesthesiology, Experimental Laboratory for VItal Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
David N NaumannSurgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
Nicole A M DekkerDepartment of Anesthesiology, Experimental Laboratory for VItal Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Peter L HordijkDepartment of Physiology, Experimental Laboratory for VItal Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Sam D HutchingsAcademic Department of Military Anesthesia and Critical Care, Royal Centre for Defense Medicine, Birmingham, UK.
Christa BoerDepartment of Anesthesiology, Experimental Laboratory for VItal Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Charissa E van den BromDepartment of Anesthesiology, Experimental Laboratory for VItal Signs, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndothelial hyperpermeability is suggested to play a role in the development of microcirculatory perfusion disturbances and organ failure following hemorrhagic shock, but evidence is limited.

objectiveTo study the effect of plasma from traumatic hemorrhagic shock patients on in vitro endothelial barrier function.

methodsPlasma from traumatic hemorrhagic shock patients was obtained at the emergency department (ED), the intensive care unit (ICU), 24 h after ICU admission and from controls (n = 8). Sublingual microcirculatory perfusion was measured using incident dark field videomicroscopy at matching time points. Using electric cell-substrate impedance sensing, the effects of plasma exposure on in vitro endothelial barrier function of human endothelial cells were assessed.

resultsPlasma from traumatic hemorrhagic shock patients collected at ED admission induced a 19% loss of in vitro endothelial resistance compared to plasma from controls (p < 0.001). This loss was due to reduced cell-cell contacts (p < 0.01). Plasma withdrawn at later time points did not affect endothelial barrier function (p > 0.99). Interestingly, in vitro endothelial resistance showed a positive association with in vivo microcirculatory perfusion (r = 0.56, p < 0.01).

conclusionsPlasma from traumatic hemorrhagic shock patients obtained following ED admission, but not at later stages, induced in vitro endothelial hyperpermeability. This coincided with in vivo microcirculatory perfusion disturbances.

Indexed as

AdultEndothelial CellsFemaleHumansIntensive Care UnitsMaleMiddle AgedShock, HemorrhagicYoung Adultendothelial barrier functionendothelial permeabilityHemorrhagic shockmicrocirculationplasma

Identifiers

PMID31929146
PMCPMC7504990

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.