Evidence map›Paper›PMID 31929116›Full record

ArticleAging2020

Integrated transcriptome expression profiling reveals a novel lncRNA associated with L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.

Chun-Lei Han, Yun-Peng Liu, Yun-Peng Sui, Ning Chen, Ting-Ting Du, Ying Jiang, Chen-Jia Guo, Kai-Liang Wang, Qiao Wang, Shi-Ying Fan and 4 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Chun-Lei HanDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yun-Peng LiuDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yun-Peng SuiDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Ning ChenDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ting-Ting DuDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Ying JiangDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Chen-Jia GuoDepartment of Pathology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Kai-Liang WangDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Qiao WangDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Shi-Ying FanDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Michitomo ShimabukuroDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Fan-Gang MengDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Fang YuanDepartment of Pathophysiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jian-Guo ZhangDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Beijing Institute of Neurosurgery · CNCapital Medical University · CNBeijing Tian Tan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levodopa-induced dyskinesia (LID) is a common complication of chronic dopamine replacement therapy in the treatment of Parkinson's disease (PD). Long noncoding RNAs regulate gene expression and participate in many biological processes. However, the role of long noncoding RNAs in LID is not well understood. In the present study, we examined the lncRNA transcriptome profile of a rat model of PD and LID by RNA sequence and got a subset of lncRNAs, which were gradually decreased during the development of PD and LID. We further identified a previously uncharacterized long noncoding RNA, NONRATT023402.2, and its target genes glutathione S-transferase omega

Indexed as

RNA, Long NoncodingTranscriptomeAnimalsAntiparkinson AgentsBiomarkersComputational BiologyDisease Models, AnimalDyskinesiasGene Expression ProfilingGene Regulatory NetworksImmunohistochemistryLevodopaModels, BiologicalParkinson DiseaseRatsAntiparkinson AgentsBiomarkersLevodopaRNA, Long Noncodinglevodopa-induced dyskinesialong noncoding RNAParkinson’s diseaseRNA sequencing

Identifiers

PMID31929116
PMCPMC6977703
OpenAlexW2999912233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.