ArticleAging2020
Prediction of hepatocellular carcinoma prognosis based on expression of an immune-related gene set.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Development and Validation of the novel Cuproptosis- and Immune-related Signature for Predicting Prognosis in Hepatocellular Carcinoma.Journal of Cancer · 2024Article
- Article
- Glycolytic and fatty acid oxidation genes affect the treatment and prognosis of liver cancer.World journal of clinical cases · 2022Article
- Article
- Prediction of hepatocellular carcinoma risk in patients with chronic liver disease from dynamic modular networks.Journal of translational medicine · 2021Article
- Development and validation of an immune gene-set based prognostic signature for soft tissue sarcoma.BMC cancer · 2021Article
- An independent poor-prognosis subtype of hepatocellular carcinoma based on the tumor microenvironment.The Journal of international medical research · 2021Article
- Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.Scientific reports · 2021Article
- Model based on five tumour immune microenvironment-related genes for predicting hepatocellular carcinoma immunotherapy outcomes.Journal of translational medicine · 2021Article
- Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma.International journal of general medicine · 2021Article
- A prognostic risk model based on immune-related genes predicts overall survival of patients with hepatocellular carcinoma.Health science reports · 2020Article
- Comprehensive profiling of immune-related genes in soft tissue sarcoma patients.Journal of translational medicine · 2020Article
- Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues.Journal of translational medicine · 2020Article
- Article
- Emerging Role of Immunotherapy for Colorectal Cancer with Liver Metastasis.OncoTargets and therapy · 2020Review
- In-depth characterization of the biomarkers based on tumor-infiltrated immune cells reveals implications for diagnosis and prognosis in hepatocellular carcinoma.Journal of translational autoimmunity · 2020Article
- A Molecular Subtype Model for Liver HBV-Related Hepatocellular Carcinoma Patients Based on Immune-Related Genes.Frontiers in oncology · 2020Article
- Correlations between stemness indices for hepatocellular carcinoma, clinical characteristics, and prognosis.American journal of translational research · 2020Article
- A Novel Signature Based on mTORC1 Pathway in Hepatocellular Carcinoma.Journal of oncology · 2020Article
- Identification of the Prognostic Value of Immune-Related Genes in Esophageal Cancer.Frontiers in genetics · 2020Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is a common type of malignant tumor with an extremely poor prognosis. Because many HCC patients are diagnosed with advanced disease, surgical treatment is typically not possible, and other currently available treatments are often ineffective. Immunotherapy is being explored as a new treatment method for a variety of cancers, including HCC. However, there have been no systematic reports about the relationship between immune-related genes and HCC patient prognosis. In this study, we established and verified a gene set-based model to examine the relationship between immune-related genes and prognosis in HCC patients. The model was based on a dataset from The Cancer Genome Atlas (TCGA), and its stability and reliability was confirmed in four verification datasets. In addition, we performed multivariate Cox regression analyses to identify the independent risk factors affecting HCC patient prognoses. We found that this new model based on immune-related genes was effective for predicting prognosis, evaluating disease state, and identifying treatment options for HCC patients.
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