Trial reportBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Magnetoencephalographic Correlates of Suicidal Ideation in Major Depression.
Trial report in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04877977 (Long-term Observation of Participants With Mood Disorders), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Observation of Participants With Mood Disorders
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Neurophysiological biomarkers of treatment response in suicidal ideation: a systematic review.Translational psychiatry · 2025Pooled it
- Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies.The lancet. Psychiatry · 2023Pooled it
- Magnetoencephalography biomarkers of suicide attempt history and antidepressant response to ketamine in treatment-resistant major depression.Journal of affective disorders · 2022Trial
- Uncovering oscillatory dysregulation associated with suicide risk in major depressive disorder: a narrative review.Translational psychiatry · 2026Review
- Gamma-band cortical functional network abnormalities in late-life depression with suicidal ideation: insights from EEG graph theory and machine learning.Journal of psychiatry & neuroscience : JPN · 2026Article
- Plasma copeptin is coupled to resting-state frontoinsular-subgenual alpha dynamics in major depression with comorbid post-traumatic stress disorder.Frontiers in endocrinology · 2026Article
- γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.Military Medical Research · 2025Review
- Clinical indicators of the suicide crisis and response to ketamine.Journal of affective disorders · 2025Article
- Effects of Ketamine on Frontoparietal Interactions in a Rule-Based Antisaccade Task in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Potential association between suicide risk, aggression, impulsivity, and the somatosensory system.Social cognitive and affective neuroscience · 2024Article
- Clinical, behavioral, and electrophysiological profiles along a continuum of suicide risk: evidence from an implicit association task.Psychological medicine · 2024Article
- Clinical and electrophysiological correlates of hopelessness in the context of suicide riskEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024Article
- An International Classification of Functioning, Disability and Health Model-Based Analysis of Suicidal Ideation among 9920 Community-Dwelling Korean Older Adults.Healthcare (Basel, Switzerland) · 2024Article
- Targeting suicidal ideation in major depressive disorder with MRI-navigated Stanford accelerated intelligent neuromodulation therapy.Translational psychiatry · 2024Article
- A computational model to characterize the time-course of response to rapid antidepressant therapies.PloS one · 2024Article
- Suicide prevention and ketamine: insights from computational modeling.Frontiers in psychiatry · 2023Review
- Spontaneous transient states of fronto-temporal and default-mode networks altered by suicide attempt in major depressive disorder.European archives of psychiatry and clinical neuroscience · 2022Article
- Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review.Frontiers in psychiatry · 2022Review
- New Methods for Assessing Rapid Changes in Suicide Risk.Frontiers in psychiatry · 2021Review
- Ketamine and Attentional Bias Toward Emotional Faces: Dynamic Causal Modeling of Magnetoencephalographic Connectivity in Treatment-Resistant Depression.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDefining the neurobiological underpinnings of suicidal ideation (SI) is crucial to improving our understanding of suicide. This study used magnetoencephalographic gamma power as a surrogate marker for population-level excitation-inhibition balance to explore the underlying neurobiology of SI and depression. In addition, effects of pharmacological intervention with ketamine, which has been shown to rapidly reduce SI and depression, were assessed.
methodsData were obtained from 29 drug-free patients with major depressive disorder who participated in an experiment comparing subanesthetic ketamine (0.5 mg/kg) with a placebo saline infusion. Magnetoencephalographic recordings were collected at baseline and after ketamine and placebo infusions. During scanning, patients rested with their eyes closed. SI and depression were assessed, and a linear mixed-effects model was used to identify brain regions where gamma power and both SI and depression were associated. Two regions of the salience network (anterior insula, anterior cingulate) were then probed using dynamic causal modeling to test for ketamine effects.
resultsClinically, patients showed significantly reduced SI and depression after ketamine administration. In addition, distinct regions in the anterior insula were found to be associated with SI compared with depression. In modeling of insula-anterior cingulate connectivity, ketamine lowered the membrane capacitance for superficial pyramidal cells. Finally, connectivity between the insula and anterior cingulate was associated with improvements in depression symptoms.
conclusionsThese findings suggest that the anterior insula plays a key role in SI, perhaps via its role in salience detection. In addition, transient changes in superficial pyramidal cell membrane capacitance and subsequent increases in cortical excitability might be a mechanism through which ketamine improves SI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.