Evidence map›Paper›PMID 31928911›Full record

ArticleSchizophrenia research2020

Age dependent association of inbreeding with risk for schizophrenia in Egypt.

Lora McClain, Hader Mansour, Ibtihal Ibrahim, Lambertus Klei, Warda Fathi, Joel Wood, Chowdari Kodavali, Alina Maysterchuk, Shawn Wood, Farha El-Chennawi and 14 more

Open access · greenAbstract read
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In one paragraph

Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 2 countries.

Lora McClainDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.
Hader MansourDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA; Department of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Ibtihal IbrahimDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Lambertus KleiDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.
Warda FathiDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Joel WoodDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.
Chowdari KodavaliDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.
Alina MaysterchukDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.
Shawn WoodDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.
Farha El-ChennawiDepartment of Clinical Pathology, Mansoura University School of Medicine, Mansoura, Egypt.
Nahed IbrahimDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.
Ahmed EissaDepartment of Psychiatry and Neuropsychiatry, Port Said University, Port Said, Egypt.
Wafaa El-BahaeiDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Hanan El SayedDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Amal YasseinDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Salwa TobarDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Hala El-BoraieDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Eman El-SheshtawyDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Hala SalahDepartment of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt.
Ahmed AliDepartment of Clinical Pathology, Mansoura University Student Hospital, Mansoura, Egypt.
Serkan ErdinCenter for Genomic Medicine, Department of Neurology, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, MA, USA.
Bernie DevlinDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA.
Michael TalkowskiCenter for Genomic Medicine, Department of Neurology, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, MA, USA.
Vishwajit NimgaonkarDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Hospital, Pittsburgh, PA, USA; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: vishwajitnl@upmc.edu.
Mansoura University · EGUniversity of Pittsburgh · USHarvard University · USMansoura University Hospital · EGPort Said University · EG

Funding

YEAST ER MOLECULAR CHAPERONE TRANSLOCATION: GENOME DATABANK HOMOLOGSP41RR006009 · NCRR · MELLON PITTS CORPORATION (MPC CORP) · PI ROPELEWSKI, ALEXANDER J · 1990 to 2011
$22.0M
Genetics Association in Schizophrenia and Other DisordersR37MH057881 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEVLIN, BERNIE · 2013 to 2022
$5.4M
Psychiatric research infrastructure for intervention and implementation in India – TEAMSD43TW009114 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Smita N Deshpande, Mary Elizabeth Hawk · 2014 to 2026
$3.2M
Genetic Susceptibility in SchizophreniaR01MH056242 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2002 to 2007
$2.9M
Multi-pronged genetic studies of schizophrenia in an inbred populationR01MH093246 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANSOUR, HADER A., NIMGAONKAR, VISHWAJIT LAXMIKANT · 2012 to 2016
$2.6M
Training Program for Psychiatric Genetics in IndiaD43TW006167 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2002 to 2006
$1.7M
GENETIC SUSCEPTIBILITY IN SCHIZOPHRENIAR10MH056242 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 1997 to 2001
$1.2M
Tri National Training Program in Psychiatric GeneticsD43TW008302 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANSOUR, HADER A., NIMGAONKAR, VISHWAJIT LAXMIKANT · 2009 to 2013
$542k
3/5:Family-Based Genome-Wide Methylation Scan in Neurocognition and SchizophreniaRC2MH089859 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2009 to 2010
$501k
Building Sustainable Research Capacity at Mansoura EgyptR21TW007997 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2007 to 2008
$236k
3/5: A Genome-Wide Methylation Scan for Epigenetic Contributions to SchizophreniaU01MH085269 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2008 to 2012
$187k
Consanguinity and risk of Bipolar Disorder I in EgyptR03TW006949 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2005 to 2007
$110k
FIC NIH HHS D43 TW006167FIC NIH HHS D43 TW008302FIC NIH HHS D43 TW009114FIC NIH HHS R03 TW006949FIC NIH HHS R21 TW007997NCRR NIH HHS P41 RR006009NIMH NIH HHS R01 MH056242NIMH NIH HHS R01 MH093246NIMH NIH HHS R10 MH056242NIMH NIH HHS R37 MH057881NIMH NIH HHS RC2 MH089859NIMH NIH HHS U01 MH085269
6 · The paper itself

Abstract

backgroundSelf-reported consanguinity is associated with risk for schizophrenia (SZ) in several inbred populations, but estimates using DNA-based coefficients of inbreeding are unavailable. Further, it is not known whether recessively inherited risk mutations can be identified through homozygosity by descent (HBD) mapping.

methodsWe studied self-reported and DNA-based estimates of inbreeding among Egyptian patients with SZ (n = 421, DSM IV criteria) and adult controls without psychosis (n = 301), who were evaluated using semi-structured diagnostic interview schedules and genotyped using the Illumina Infinium PsychArray. Following quality control checks, coefficients of inbreeding (F) and regions of homozygosity (ROH) were estimated using PLINK software for HBD analysis. Exome sequencing was conducted in selected cases.

resultsInbreeding was associated with schizophrenia based on self-reported consanguinity (χ

conclusionsWe propose consanguinity as an age-dependent risk factor for SZ in Egypt. HBD mapping is feasible for SZ in adequately powered samples.

Indexed as

InbreedingSchizophreniaAdultConsanguinityEgyptHomozygoteHumansPolymorphism, Single NucleotideConsanguinityGenotypingPsychosisStatistical genetics

Identifiers

PMID31928911
PMCPMC8054776
OpenAlexW2999174165

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.