Evidence map›Paper›PMID 31928762›Full record

ArticleBiophysical journal2020

A Bistable Mechanism Mediated by Integrins Controls Mechanotaxis of Leukocytes.

Alexander Hornung, Thomas Sbarrato, Nicolas Garcia-Seyda, Laurene Aoun, Xuan Luo, Martine Biarnes-Pelicot, Olivier Theodoly, Marie-Pierre Valignat

Abstract read
In one paragraph

Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Natural Killer Cell Mechanosensing in Solid Tumors.Bioengineering (Basel, Switzerland) · 2024
    Review
  5. Review
  6. Review
  7. Keratocytes migrate against flow with a roly-poly-like mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Review
  9. Review
  10. A Darwinian perspective on tumor immune evasion.Biochimica et biophysica acta. Reviews on cancer · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Visualization of integrin molecules by fluorescence imaging and techniques.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2021
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander HornungAix Marseille University, CNRS, INSERM, LAI, Marseille, France.
Thomas SbarratoAix Marseille University, CNRS, INSERM, LAI, Marseille, France.
Nicolas Garcia-SeydaAix Marseille University, CNRS, INSERM, LAI, Marseille, France.
Laurene AounAix Marseille University, CNRS, INSERM, LAI, Marseille, France.
Xuan LuoAix Marseille University, CNRS, INSERM, LAI, Marseille, France.
Martine Biarnes-PelicotAix Marseille University, CNRS, INSERM, LAI, Marseille, France.
Olivier TheodolyAix Marseille University, CNRS, INSERM, LAI, Marseille, France.
Marie-Pierre ValignatAix Marseille University, CNRS, INSERM, LAI, Marseille, France. Electronic address: marie-pierre.valignat@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recruitment of leukocytes from blood vessels to inflamed zones is guided by biochemical and mechanical stimuli, with the mechanisms only partially deciphered. Here, we studied the guidance by the flow of primary human effector T lymphocytes crawling on substrates coated with ligands of integrins lymphocyte function-associated antigen 1 (LFA-1) (α

Indexed as

IntegrinsVascular Cell Adhesion Molecule-1Cell AdhesionHumansIntegrin alpha4beta1Intercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1T-LymphocytesIntegrin alpha4beta1IntegrinsIntercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1Vascular Cell Adhesion Molecule-1

Identifiers

PMID31928762
PMCPMC7002925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.