Evidence map›Paper›PMID 31928179›Full record

ArticleCirculation research2020

Sympathetic Enhancement of Memory T-Cell Homing and Hypertension Sensitization.

Liang Xiao, Luciana Simao do Carmo, Jason D Foss, Wei Chen, David G Harrison

Open access · greenAbstract read
In one paragraph

Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Review
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  7. Article
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  9. Review
  10. Immune Mechanisms in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2024
    Review
  11. Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024
    Review
  12. Hypertension (Dallas, Tex. : 1979) · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Liang XiaoFrom the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (L.X., L.S.d.C., W.C., D.G.H.).
Luciana Simao do CarmoFrom the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (L.X., L.S.d.C., W.C., D.G.H.).
Jason D FossPlato BioPharma, Westminster, CO (J.D.F.).
Wei ChenFrom the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (L.X., L.S.d.C., W.C., D.G.H.).
David G HarrisonFrom the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (L.X., L.S.d.C., W.C., D.G.H.).
Vanderbilt University Medical Center · USARCA Biopharma (United States) · US

Funding

The Role of Inflammation in Cardiovascular DiseaseP01HL129941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNSTEIN, KENNETH E · 2016 to 2020
$12.4M
Mechanisms of Immune Activation in HypertensionR35HL140016 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 2018 to 2024
$5.3M
NHLBI NIH HHS P01 HL129941NHLBI NIH HHS R35 HL140016
6 · The paper itself

Abstract

rationaleEffector memory T lymphocytes (T

objectiveBecause hypertension is associated with increased sympathetic outflow to the bone marrow, we hypothesized that sympathetic nerves regulate accumulation and reactivation of bone marrow-residing hypertension-specific T METHODS AND

resultsUsing unilateral superior cervical ganglionectomy in wild-type C57BL/6 mice, we showed that sympathetic nerves create a bone marrow environment that supports residence of hypertension-specific CD8

conclusionsSympathetic nerves contribute to the homing and survival of hypertension-specific T

Indexed as

Cell MovementAdoptive TransferAdrenergic beta-2 Receptor AntagonistsAngiotensin IIAnimalsBone MarrowCD8-Positive T-LymphocytesDenervationHypertensionMedulla OblongataMiceMice, Inbred C57BLReceptors, Adrenergic, beta-2Superior Cervical GanglionAdrenergic beta-2 Receptor AntagonistsAngiotensin IIReceptors, Adrenergic, beta-2angiotensin IIdendritic cellsganglionectomyhypertensioninflammation

Identifiers

PMID31928179
PMCPMC8253247
OpenAlexW2999741749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.