ReviewTissue engineering. Part B, Reviews2020
Histological Review of Demineralized Dentin Matrix as a Carrier of rhBMP-2.
Review in Tissue engineering. Part B, Reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Bone graft substitutes and dental implant stability in immediate implant surgery: a systematic review and meta-analysis.Evidence-based dentistry · 2025Pooled it
- Trial
- Long-Term Bone Healing Using Autogenous Tooth Bone Graft Combined with rhBMP-2 after Enucleation of a Large Odontogenic Keratocyst: A Case Report.Tissue engineering and regenerative medicine · 2026Article
- Geometry-Dependent Osteogenic Performance of Demineralized Dentin Matrix as a Carrier for rhBMP-2.Tissue engineering and regenerative medicine · 2026Article
- Efficacy of sinus crestal elevation with demineralized dentin matrix at the apex of the implants.International journal of implant dentistry · 2026Article
- Research Trends in Autogenous Dentin Graft: A Bibliometric and Cluster Analysis (2006-2025).International dental journal · 2026Article
- Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications.Tissue engineering and regenerative medicine · 2026Review
- Clinical and Histological Outcomes of Autologous Dentin Matrix in Post-Extraction Alveolar Healing: A Pilot Randomized Clinical Trial.Journal of clinical medicine · 2026Article
- Clinical Application of rhBMP-2 and Three-Dimensinal Preformed Titanium Mesh with Allograft and Xenograft for Peri-Implant Horizontal and Vertical Bone Augmentation-A Narrative Review with Technical Report.Journal of clinical medicine · 2025Review
- The Impact of a Human Bone Morphogenetic Protein-infused Nano-Bone Material Combined With Traditional Chinese Medicine Carthamus tinctorius on the Repair of Oral Bone Defects.International dental journal · 2025Article
- Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion.Bioactive materials · 2025Article
- Reducing Healing Period with DDM/rhBMP-2 Grafting for Early Loading in Dental Implant Surgery.Tissue engineering and regenerative medicine · 2025Article
- Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel.Biomaterials research · 2025Article
- Application of collagen in bone regeneration.Journal of orthopaedic translation · 2025Review
- Demineralized dentin matrix for bone regeneration in dentistry: A critical update.The Saudi dental journal · 2024Review
- Comparison of the osteogenic effects of demineralized dentin matrix and acellular dentin matrix.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Article
- Combination adipose-derived mesenchymal stem cells-demineralized dentin matrix increase bone marker expression in periodontitis rats.The Saudi dental journal · 2023Article
- Incorporating Moldable Demineralized Dentin Matrix into Treatment for a Jaw Cyst.Journal of functional biomaterials · 2023Article
- Biomimetic, biodegradable and osteoinductive treated dentin matrix/α-calcium sulphate hemihydrate composite material for bone tissue engineering.Regenerative biomaterials · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2007, recombinant human bone morphogenetic protein-2 (rhBMP-2) was approved for use in humans at a concentration of 1.5 mg/mL with absorbable collagen sponges as an alternative to autogenous bone grafts for alveolar ridge augmentation, defects associated with extraction sockets, and sinus augmentation. However, the use of supraphysiological doses and the insufficient retention of rhBMP-2, when delivered through collagen sponge, result in dose-dependent side effects related to off-label use. Demineralized dentin matrix (DDM), an osteoinducing bone substrate, has been used as an rhBMP-2 carrier since 1998. In addition, DDM has both microparticle and nanoparticle structures, which do not undergo remodeling, unlike bone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.