ArticleGut microbes2020
Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice.
Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation.American journal of hematology · 2026Review
- Loss of GLP-2R signaling in Glp2rMolecular metabolism · 2026Article
- Graft-Versus-Host Disease Mouse Models: A Clinical-Translational Perspective.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Characterization of Vitreous Microbiota Dysbiosis Associated with Proliferative Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Review
- Article
- Impact of weight variation on the microbiome of yak dams and calves.Frontiers in microbiology · 2024Article
- Hydrogenotrophic methanogenesis is the key process in the obligately syntrophic consortium of the anaerobic ameba Pelomyxa schiedti.The ISME journal · 2023Article
- Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity.Immunity · 2023Article
- IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans.Microbiome · 2023Article
- Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation.Immunity · 2023Article
- Characterization of the bacterial microbiome of Swedish ticks through 16S rRNA amplicon sequencing of whole ticks and of individual tick organs.Parasites & vectors · 2023Article
- 2bRAD-M reveals the difference in microbial distribution between cancerous and benign ovarian tissues.Frontiers in microbiology · 2023Article
- The microbiome-the revealing of a long time unbeknownst factor for outcome in murine models of graft-versus-host disease.Bone marrow transplantation · 2021Review
- Links between fecal microbiota and the response to vaccination against influenza A virus in pigs.NPJ vaccines · 2021Article
- Crosstalk Between Intestinal Microbiota Derived Metabolites and Tissues in Allogeneic Hematopoietic Cell Transplantation.Frontiers in immunology · 2021Review
- Associations between the Gut Microbiota, Immune Reconstitution, and Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation.Immunometabolism · 2021Article
- Microbiome: an emerging new frontier in graft‑versus‑host disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Article
- Article
Corrections and comments
- Erratum issuedCorrection.2020
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe gut microbiome plays a key role in the development of acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation. Here we investigate the individual contribution of the pre- and post-transplant gut microbiome to acute GVHD using a well-studied mouse model.
designWild-type mice were cohoused with IL-17RA
resultsPriming wild-type mice via cohousing pre-transplant only is insufficient to accelerate GVHD, however, accelerated disease is observed in WT mice cohoused post-transplant only. When mice are cohoused continuously, the effect of priming and exacerbation is additive, resulting in a greater acceleration of disease in WT mice beyond that seen with cohousing post-transplant only. Metagenomic analysis of the microbiome revealed pre-transplant cohousing is associated with the transfer of specific species within two as-yet-uncultured genera of the bacterial family
conclusionThese results clarify the importance of the peri-transplant microbiome in the susceptibility to acute GVHD post-transplant and demonstrate the species-specific nature of this association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.