Evidence map›Paper›PMID 31928113›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Hypertensive Complications of Pregnancy and Risk of Venous Thromboembolism.

Luuk J J Scheres, Willem M Lijfering, Norbert F M Groenewegen, Sanne Koole, Christianne J M de Groot, Saskia Middeldorp, Suzanne C Cannegieter

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
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  8. Observational
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  11. Pregnancy complications and later life women's health.Acta obstetricia et gynecologica Scandinavica · 2023
    Review
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Luuk J J ScheresFrom the Department of Clinical Epidemiology (L.J.J.S., W.M.L., S.C.C.), Leiden University Medical Center, the Netherlands.
Willem M LijferingFrom the Department of Clinical Epidemiology (L.J.J.S., W.M.L., S.C.C.), Leiden University Medical Center, the Netherlands.
Norbert F M GroenewegenDutch Federation of Anticoagulation Clinics, Leiden, the Netherlands (N.F.M.G.).
Sanne KoolePerined, Utrecht, the Netherlands (S.K.).
Christianne J M de GrootDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit, the Netherlands (C.J.M.d.G.).
Saskia MiddeldorpDepartment of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands (L.J.J.S., S.M.).
Suzanne C CannegieterFrom the Department of Clinical Epidemiology (L.J.J.S., W.M.L., S.C.C.), Leiden University Medical Center, the Netherlands.
Leiden University Medical Center · NLAmsterdam University Medical Centers · NLUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension during pregnancy and preeclampsia are associated with increased arterial thrombotic risk in later life. Whether these complications are associated with risk of venous thromboembolism (VTE) on the short term after pregnancy and on the long term, that is, outside pregnancy, is largely unknown. We conducted a nationwide cohort study in women with at least 1 pregnancy and their first VTE risk by linking the Dutch perinatal registry (Perined) to anticoagulation clinics. We used Cox proportional hazard models to estimate hazard ratios (HRs) and corresponding 95% CI for VTE risk in women with hypertension during pregnancy, women with preeclampsia, compared with women with uncomplicated pregnancies (reference). A total of 1 919 918 women were followed for a median of 13.7 (interquartile range, 7.6-19.2) years for a total of 24 531 118 person-years in which 5759 first VTEs occurred; incidence rate: 2.3 (95% CI, 2.3-2.4) per 10 000 person-years. In the first pregnancy and 3-month postpartum period, VTE risk was higher in women with hypertension, HR, 2.0 (95% CI, 1.7-2.4), and highest among women with preeclampsia, HR, 7.8 (95% CI, 5.4-11.3), versus the reference group. On the long term, women with hypertension during pregnancy and preeclampsia had a higher VTE risk: HR, 1.5 (95% CI, 1.4-1.6) and HR, 2.1 (95% CI, 1.8-2.4), respectively, versus the reference group. When excluding events during pregnancy and postpartum, these HRs were 1.4 (95% CI, 1.3-1.5) and 1.6 (95% CI, 1.4-2.0), respectively. In conclusion, hypertension during pregnancy and preeclampsia are associated with an increased VTE risk during pregnancy and postpartum period and in the 13 years after.

Indexed as

AdultFemaleFollow-Up StudiesHumansHypertension, Pregnancy-InducedIncidenceNetherlandsPre-EclampsiaPregnancyPuerperal DisordersPulmonary EmbolismRiskThrombophiliaVenous ThromboembolismVenous Thrombosishypertensionpreeclampsiapregnancyriskvenous thromboembolism

Identifiers

PMID31928113
PMCPMC8032207
OpenAlexW2999329364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.