Evidence map›Paper›PMID 31928012›Full record

ArticleJournal of proteome research2020

Proteomic Analysis of MYB-Regulated Secretome Identifies Functional Pathways and Biomarkers: Potential Pathobiological and Clinical Implications.

Haseeb Zubair, Girijesh Kumar Patel, Mohammad Aslam Khan, Shafquat Azim, Asif Zubair, Seema Singh, Sanjeev Kumar Srivastava, Ajay Pratap Singh

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Proteomics in pancreatic cancer.Biomarker research · 2025
    Review
  4. Role of ENO1 and its targeted therapy in tumors.Journal of translational medicine · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Haseeb ZubairDepartment of Pathology, College of Medicine , University of South Alabama , Mobile , Alabama 36617 , United States.
Girijesh Kumar PatelMitchell Cancer Institute , University of South Alabama , 1660 Springhill Avenue , Mobile , Alabama 36604 , United States.
Mohammad Aslam KhanDepartment of Pathology, College of Medicine , University of South Alabama , Mobile , Alabama 36617 , United States.
Shafquat AzimMitchell Cancer Institute , University of South Alabama , 1660 Springhill Avenue , Mobile , Alabama 36604 , United States.
Asif ZubairMolecular and Computational Biology, School of Biological Sciences, Dornsife College of Letters, Arts and Sciences , University of Southern California , Los Angeles , California 90089 , United States.
Seema SinghDepartment of Pathology, College of Medicine , University of South Alabama , Mobile , Alabama 36617 , United States.
Sanjeev Kumar SrivastavaDepartment of Pathology, College of Medicine , University of South Alabama , Mobile , Alabama 36617 , United States.
Ajay Pratap SinghDepartment of Pathology, College of Medicine , University of South Alabama , Mobile , Alabama 36617 , United States.ORCID 0000-0003-3492-6330
USA Mitchell Cancer Institute · USUniversity of Southern California · US

Funding

Targeting tumor-stromal interaction for pancreatic cancer therapyR01CA175772 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI SINGH, AJAY PRATAP · 2014 to 2018
$1.9M
A novel molecular cross-talk driving pancreatic cancer progressionR01CA224306 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI SINGH, AJAY PRATAP · 2018 to 2022
$1.7M
Molecular determinant of racial disparity in prostate cancerU01CA185490 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI SINGH, AJAY PRATAP · 2014 to 2018
$1.7M
NCI NIH HHS R01 CA175772NCI NIH HHS R01 CA224306NCI NIH HHS U01 CA185490
6 · The paper itself

Abstract

Earlier we have shown important roles of MYB in pancreatic tumor pathobiology. To better understand the role of MYB in the tumor microenvironment and identify MYB-associated secreted biomarker proteins, we conducted mass spectrometry analysis of the secretome from MYB-modulated and control pancreatic cancer cell lines. We also performed in silico analyses to determine MYB-associated biofunctions, gene networks, and altered biological pathways. Our data demonstrated significant modulation (

Indexed as

Pancreatic NeoplasmsProteomicsBiomarkersBiomarkers, TumorHumansPhosphatidylinositol 3-KinasesSignal TransductionTumor MicroenvironmentBiomarkersBiomarkers, TumorPhosphatidylinositol 3-Kinasesbiomarkersfunctional pathwaysMYBpancreatic cancer, secretomeproteomics

Identifiers

PMID31928012
PMCPMC7700759
OpenAlexW2999368016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.