Evidence map›Paper›PMID 31927786›Full record

ArticleJournal of internal medicine2020

Incidence of myeloproliferative neoplasms - trends by subgroup and age in a population-based study in Sweden.

M Hultcrantz, A Ravn Landtblom, B Andréasson, J Samuelsson, P W Dickman, S Y Kristinsson, M Björkholm, T M-L Andersson

Open access · greenAbstract read
In one paragraph

Article in Journal of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  4. [Progress in the study of polycythemia vera in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
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  13. Polycythaemia vera.Nature reviews. Disease primers · 2025
    Review
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

M HultcrantzDepartment of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-9045-6495
A Ravn LandtblomDepartment of Medicine, Stockholm South Hospital and Karolinska Institutet, Stockholm, Sweden.
B AndréassonHematology Section, NU Hospital Group, Uddevalla, Sweden.
J SamuelssonDepartment of Hematology, University Hospital Linkoping, Linkoping, Sweden.
P W DickmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
S Y KristinssonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
M BjörkholmDepartment of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
T M-L AnderssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SELinköping University Hospital · SEMemorial Sloan Kettering Cancer Center · USNU Hospital Group · SEUniversity of Iceland · IS

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThe reported incidence of Philadelphia-negative myeloproliferative neoplasms (MPNs) differs substantially between previous reports, likely due to true regional differences in incidence and/or variations in the quality and coverage of the cancer registers.

objectiveWe therefore assessed MPN incidence in Sweden during recent years using prospectively collected information captured in Swedish health registers.

methodsPatients with MPNs were identified through the Swedish Cancer Register and Swedish Blood Cancer Register between 2000 and 2014. Information on the Swedish population was obtained from the Human Mortality Database. Crude and age-standardized incidence rates of MPNs with 95% confidence intervals (CIs) were calculated.

resultsA total of 6281 MPN cases were reported to the Swedish Cancer Register and Swedish Blood Cancer Register during 2000-2014. The age-standardized, to the Swedish population in 2000, incidence for all MPNs was 4.45 (95% confidence interval [CI] 4.34-4.56)/100 000 person-years. The age-standardized incidence for polycythemia vera was 1.48 (1.42-1.54), for essential thrombocythemia 1.60 (1.53-1.66) and for primary myelofibrosis 0.52 (0.48-0.56)/100 000 person-years, respectively. The incidence rate of MPNs was substantially higher in the older compared to the younger age groups. The incidence increased during the study period, likely to do better reporting and increasing age of the general population.

conclusionThe reported MPN incidences in our study, which were in the higher interval of previously published studies, are likely more accurate compared to previous reports due to the population-based setting and high level of coverage in the Swedish Cancer and Blood Cancer Registers.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsBone Marrow NeoplasmsFemaleHumansIncidenceMaleMiddle AgedPolycythemia VeraPrimary MyelofibrosisProspective StudiesRegistriesSwedenessential thrombocythemiaincidencemyeloproliferative neoplasmspolycythemia veraprimary myelofibrosis

Identifiers

PMID31927786
PMCPMC7598815
OpenAlexW3000314328

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.