SynthesisInternational ophthalmology2020
Multimodal imaging patterns of posterior syphilitic uveitis: a review of the literature, laboratory evaluation and treatment.
Synthesis in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Questions Ophthalmology Trainees Ask About Ocular Syphilis: A Question-Driven Narrative Review.Cureus · 2026Review
- Advanced Multimodal Imaging in Granulomatous Uveitis: From Differential Diagnosis to Treatment Monitoring and Surgical Integration.Journal of clinical medicine · 2026Review
- Syphilitic Uveitis in HIV-Positive and -Negative Patients: A Multicenter Cohort Study.Turkish journal of ophthalmology · 2026Article
- Syphilitic Panuveitis and Rhegmatogenous Retinal Detachment: Diagnostic Pitfalls and Treatment Considerations.Medicina (Kaunas, Lithuania) · 2026Review
- Genome-sequencing of ocular fluid in a patient with syphilitic uveitis: Strain identification and antimicrobial resistance detection.American journal of ophthalmology case reports · 2026Article
- Infectious optic neuropathy: the interplay between pathogens and the host immune system-a review of diagnostic and therapeutic dilemmas.Frontiers in cellular and infection microbiology · 2026Review
- Syphilitic Uveitis: Clinical Features, Treatment, and Outcome.The American journal of case reports · 2025Article
- Clinical manifestations and treatment prognosis of patients with co-infection of ocular syphilis and HIV.BMC ophthalmology · 2025Article
- Characterization of Syphilitic Chorioretinitis as a White Dot Syndrome with Multimodal Imaging: Case Series.Diagnostics (Basel, Switzerland) · 2025Article
- Ocular vs neurosyphilis. are they the same? A guide to investigation and management.Eye (London, England) · 2024Review
- Trends in management of ocular syphilis in tertiary uveitis centre in Prague, Czech Republic.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023Article
- Clinical Features and Possible Origin of Preretinal Deposits in Different Ocular Diseases and Events: A Narrative Review.Ophthalmology and therapy · 2023Review
- Clinical features and incidence of visual improvement following systemic antibiotic treatment in patients with syphilitic uveitis.Scientific reports · 2022Article
- Acute syphilitic posterior placoid chorioretinitis: when the great mimicker cannot pretend any more; new insight of an old acquaintance.Journal of ophthalmic inflammation and infection · 2022Review
- Update on the Management of Uveitic Macular Edema.Journal of clinical medicine · 2021Review
- Syphilitic retinitis presentations: punctate inner retinitis and posterior placoid chorioretinitis.International ophthalmology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review the multimodal imaging patterns of posterior syphilitic uveitis.
methodsA systematic review.
resultsThe percentage of syphilis has started to increase again: The World Health Organization has reported 12 million new cases of syphilis each year. In addition, syphilis was responsible for 0.3% of deaths globally in 2002. Eye manifestations happen prevalently in secondary and tertiary stages of syphilis, even though ocular involvement can occur in all stages. Syphilis has the nickname: "the great imitator" since it has no unique clinical presentation, even though posterior uveitis is considered the most common form. Syphilis is known as "the great imitator," making its diagnosis in the presence of posterior uveitis particularly challenging as it presents similarly to other ocular conditions such as acute retinal necrosis. However, with the advent of multimodal imaging some particular patterns of pre-retinal, retinal, retinochoroidal and optic nerve involvement from syphilis can be identified to guide the diagnosis and the laboratory workup.
conclusionThis review highlights the various patterns of pre-retinal precipitates, multifocal retinitis, retinochoroiditis (confluent and placoid) and optic neuritis caused by syphilis, the appropriate laboratory work to be obtained and the treatment to be initiated.
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Registered trials
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