Evidence map›Paper›PMID 31927610›Full record

ArticleCellular and molecular life sciences : CMLS2020

GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity.

Rocío Vila-Bedmar, Marta Cruces-Sande, Alba C Arcones, Hanneke L D M Willemen, Patricia Prieto, Isabel Moreno-Indias, Daniel Díaz-Rodríguez, Sara Francisco, Rafael I Jaén, Carolina Gutiérrez-Repiso and 6 more

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Pharmacological inhibition of G protein-coupled receptor kinase 2 (GRK2) by paroxetine attenuates acetaminophen-induced hepatotoxicity.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Rocío Vila-BedmarDepartamento de ciencias básicas de la salud, área de Bioquímica y Biología Molecular, Universidad Rey Juan Carlos (URJC), Madrid, Spain.
Marta Cruces-SandeDepartamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid (CSIC/UAM), C/Nicolás Cabrera 1, 28049, Madrid, Spain.
Alba C ArconesDepartamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid (CSIC/UAM), C/Nicolás Cabrera 1, 28049, Madrid, Spain.
Hanneke L D M WillemenLaboratory of Translational Immunology (LTI), University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Patricia PrietoCIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Isabel Moreno-IndiasCIBER de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Daniel Díaz-RodríguezDepartamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid (CSIC/UAM), C/Nicolás Cabrera 1, 28049, Madrid, Spain.
Sara FranciscoDepartamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid (CSIC/UAM), C/Nicolás Cabrera 1, 28049, Madrid, Spain.
Rafael I JaénInstituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain.
Carolina Gutiérrez-RepisoCIBER de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Cobi J HeijnenUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lisardo BoscáCIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Manuel FresnoDepartamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid (CSIC/UAM), C/Nicolás Cabrera 1, 28049, Madrid, Spain.
Annemieke KavelaarsUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Federico MayorDepartamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid (CSIC/UAM), C/Nicolás Cabrera 1, 28049, Madrid, Spain. fmayor@cbm.csic.es.ORCID http://orcid.org/0000-0003-1434-8449
Cristina MurgaDepartamento de Biología Molecular and Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid (CSIC/UAM), C/Nicolás Cabrera 1, 28049, Madrid, Spain. cristina.murga@uam.es.
Instituto de Salud Carlos III · ESCentro de Biología Molecular Severo Ochoa · ESThe University of Texas MD Anderson Cancer Center · USHospital Universitario de La Princesa · ESInstituto de Investigaciones Biomédicas Sols-Morreale · ESUniversidad Rey Juan Carlos · ESUtrecht University · NL

Funding

Comunidad de Madrid B2017/BMD-3671Instituto de Salud Carlos III CB16/11/00222Instituto de Salud Carlos III CB16/11/00278Instituto de Salud Carlos III (ES) PI15/01114Miguel Servet type I CP16/00163Ministerio de Economía y Competitividad SAF2017-82436RMinisterio de Economía y Competitividad SAF2017-84125-RNovo Nordisk_European Association for the Study of Diabetes (DE) NA
6 · The paper itself

Abstract

Macrophages are key effector cells in obesity-associated inflammation. G protein-coupled receptor kinase 2 (GRK2) is highly expressed in different immune cell types. Using LysM-GRK2

Indexed as

Diet, High-FatAdipocytesAdipose TissueAdipose Tissue, WhiteAnimalsCulture Media, ConditionedCytoprotectionFatty LiverGastrointestinal MicrobiomeGlucoseGlucose IntoleranceG-Protein-Coupled Receptor Kinase 2HypertrophyInflammationInsulinInsulin ResistanceCulture Media, ConditionedGlucoseG-Protein-Coupled Receptor Kinase 2InsulinAdipose tissueGlucose homeostasisGRK2LiverMacrophagesObesity

Identifiers

PMID31927610
PMCPMC11105060
OpenAlexW2999560882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.