Evidence map›Paper›PMID 31927533›Full record

ArticleAging2020

Six-gene signature for predicting survival in patients with head and neck squamous cell carcinoma.

Juncheng Wang, Xun Chen, Yuxi Tian, Gangcai Zhu, Yuexiang Qin, Xuan Chen, Leiming Pi, Ming Wei, Guancheng Liu, Zhexuan Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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  4. DeSide: A unified deep learning approach for cellular deconvolution of tumor microenvironment.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juncheng WangDepartment of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
Xun ChenDepartment of Oral and Maxillofacial Surgery, First Affiliated Hospital of Quanzhou, Fujian Medical University, Quanzhou 362000, People's Republic of China.
Yuxi TianDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008 People's Republic of China.
Gangcai ZhuDepartment of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, People's Republic of China.
Yuexiang QinDepartment of Health Management, The Third Xiangya Hospital, Central South University, Changsha 410011, People's Republic of China.
Xuan ChenDepartment of Stomatology, Changzheng Hospital, Second Military Medcial University, Shanghai 200003, People's Republic of China.
Leiming PiDepartment of Otolaryngology, Head and Neck Surgery, HeYuan People's Hospital, Jinan University, He Yuan,517000, People's Republic of China.
Ming WeiDepartment of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
Guancheng LiuDepartment of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Guilin University, Guilin 541000, People's Republic of China.
Zhexuan LiDepartment of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
Changhan ChenDepartment of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
Yunxia LvDepartment of Thyroid Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.
Gengming CaiDepartment of Otolaryngology, Head and Neck Surgery, First Affiliated Hospital of Quanzhou, Fujian Medical University, Quanzhou 362000, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognosis of head and neck squamous cell carcinoma (HNSCC) patients remains poor. High-throughput sequencing data have laid a solid foundation for identifying genes related to cancer prognosis, but a gene marker is needed to predict clinical outcomes in HNSCC. In our study, we downloaded RNA Seq, single nucleotide polymorphism, copy number variation, and clinical follow-up data from TCGA. The samples were randomly divided into training and test. In the training set, we screened genes and used random forests for feature selection. Gene-related prognostic models were established and validated in a test set and GEO verification set. Six genes (

Indexed as

Biomarkers, TumorTranscriptomeComputational BiologyFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenetic VariationHumansKaplan-Meier EstimateMalePrognosisProportional Hazards ModelsROC CurveSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorbioinformaticsCNVprognostic markersTCGA

Identifiers

PMID31927533
PMCPMC6977678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.