Evidence map›Paper›PMID 31927482›Full record

ArticleiScience2020

Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant.

Marie Antoine, Kristin L Patrick, Johann Soret, Pauline Duc, Florence Rage, Rebecca Cacciottolo, Kelly E Nissen, Ruben J Cauchi, Nevan J Krogan, Christine Guthrie and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Profilin Isoforms in Health and Disease - All the Same but Different.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Marie AntoineInstitut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France.
Kristin L PatrickUniversity of California, San Francisco, CA 94143, USA.
Johann SoretInstitut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France.
Pauline DucInstitut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France.
Florence RageInstitut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France.
Rebecca CacciottoloDepartment of Physiology and Biochemistry, University of Malta, Msida, Malta.
Kelly E NissenUniversity of California, San Francisco, CA 94143, USA.
Ruben J CauchiDepartment of Physiology and Biochemistry, University of Malta, Msida, Malta.
Nevan J KroganUniversity of California, San Francisco, CA 94143, USA.
Christine GuthrieUniversity of California, San Francisco, CA 94143, USA.
Yannick GachetCentre de Biologie Integrative, University of Toulouse, CNRS, Toulouse, France.
Rémy BordonnéInstitut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France. Electronic address: remy.bordonne@igmm.cnrs.fr.
University of California, San Francisco · USCentre National de la Recherche Scientifique · FRInstitut de Génétique Moléculaire de Montpellier · FRUniversity of Malta · MTUniversité de Montpellier · FR

Funding

Pre-mRNA splicing regulation is critical for controlling macrophage activationR35GM133720 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kristin Leigh Patrick · 2019 to 2026
$3.3M
NIGMS NIH HHS R35 GM133720
6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is a devastating motor neuron disorder caused by mutations in the survival motor neuron (SMN) gene. It remains unclear how SMN deficiency leads to the loss of motor neurons. By screening Schizosaccharomyces pombe, we found that the growth defect of an SMN mutant can be alleviated by deletion of the actin-capping protein subunit gene acp1

Indexed as

Biological SciencesCell BiologyMolecular BiologyMolecular Genetics

Identifiers

PMID31927482
PMCPMC6957872
OpenAlexW2998394424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.