Evidence map›Paper›PMID 31927326›Full record

ArticlePregnancy hypertension2020

Acute kidney injury associated with preeclampsia or hemolysis, elevated liver enzymes, and low platelets syndrome.

Sarah Novotny, Nicole Lee-Plenty, Kedra Wallace, Wondwosen Kassahun-Yimer, Aswathi Jayaram, James A Bofill, James N Martin

Open access · greenAbstract read
In one paragraph

Article in Pregnancy hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Current pharmaceutical design · 2024
    Article
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  5. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sarah NovotnyDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States. Electronic address: snovotny@umc.edu.
Nicole Lee-PlentyDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States.
Kedra WallaceDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States.
Wondwosen Kassahun-YimerDepartment of Data Science at the University of Mississippi Medical Center, Jackson, MS, United States.
Aswathi JayaramDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States.
James A BofillDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States.
James N MartinDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States.
University of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
NIGMS NIH HHS P20 GM121334NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

objectiveTo determine the prevalence of acute kidney injury (AKI), placental abruption and postpartum hemorrhage in patients with preeclampsia or HELLP syndrome. STUDY

designA retrospective study of patients with preeclampsia or HELLP syndrome treated at the University of Mississippi Medical Center from January 2000 through December 2010.

main outcome measuresRelationships among the obstetric complications of placental abruption, postpartum hemorrhage, and AKI (serum creatinine >107 µmol/L) of women with preeclampsia or HELLP syndrome. Additional analysis was undertaken to explore if there was a correlation between postpartum hemorrhage/placental abruption and the severity of HELLP syndrome according to the Mississippi classification system.

resultsData from 1276 women over 11 years were included in the analysis. 67 of 466 patients (14.4%) with HELLP syndrome and 38 of 810 preeclampsia patients (4.7%) met criteria for AKI. Women with either placental abruption or postpartum hemorrhage had statistically significant increased odds of also having AKI (p < 0.01). Women with HELLP and AKI were also more likely to experience either placental abruption or postpartum hemorrhage. Women with Class 1 HELLP with placental abruption or postpartum hemorrhage were also more likely to have AKI than women with preeclampsia.

conclusionHELLP syndrome, AKI and placental abruption or postpartum hemorrhage appear to be interrelated. AKI occurs more frequently in women with HELLP syndrome with or without associated postpartum hemorrhage and placental abruption.

Indexed as

Abruptio PlacentaeAcute Kidney InjuryAdultAlanine TransaminaseAspartate AminotransferasesCreatinineFemaleHELLP SyndromeHemolysisHumansPostpartum HemorrhagePre-EclampsiaPregnancyPremature BirthRetrospective StudiesYoung AdultAlanine TransaminaseAspartate AminotransferasesCreatinineHemolysisKidneyLiverPreeclampsiaSyndrome

Identifiers

PMID31927326
PMCPMC8945252
OpenAlexW2999215940

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.