ArticleThrombosis research2020
Hemoglobin concentration and risk of arterial and venous thrombosis in 1.5 million Swedish and Danish blood donors.
Article in Thrombosis research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Risk factors for intracardiac thrombus in peripartum cardiomyopathy: a retrospective study in China.ESC heart failure · 2023Trial
- U-shaped association between hemoglobin levels and cardiometabolic multimorbidity in older adults: a large-scale cross-sectional study.BMC geriatrics · 2026Article
- Anemia as a Potent and Underrecognized Driver of Venous Thromboembolism: A Systematic Review.Journal of clinical medicine · 2026Review
- Combined Effect of Hemoglobin Levels and Obesity on the Risk of Incident Venous Thromboembolism: The Tromsø Study.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Analysis of risk factors for PICC-related venous thrombosis in patients with hematological malignancies and establishment of a nomogram prediction model.Frontiers in oncology · 2026Article
- Sodium-Glucose Cotransporter 2 Inhibitors, Erythrocytosis, and Thrombosis in Adults With Type 2 Diabetes.JAMA network open · 2025Article
- Development and validation of a predictive risk tool for VTE in women with breast cancer under chemotherapy: a cohort study in China.Breast cancer (Tokyo, Japan) · 2025Article
- Linear and non-linear relationships between red blood cell indices and cardiovascular risk factors: findings from the China National Health Survey.BMC public health · 2024Article
- Impact of chest pain on mortality in patients with acute pulmonary embolism.Scientific reports · 2024Article
- Risk factors for elective and emergency oxygenator exchanges during veno-venous extracorporeal membrane oxygenation.Perfusion · 2024Observational
- Myeloproliferative Neoplasms and Sodium-Glucose Co-Transporter-2 Inhibitors: A Case SeriesTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024Article
- High systemic inflammation response index level is associated with an increased risk of lower extremity deep venous thrombosis: a large retrospective study.Annals of medicine · 2023Article
- Covert Brain Infarcts in Patients with Philadelphia Chromosome-Negative Myeloproliferative Disorders.Journal of clinical medicine · 2021Article
- Novel Pathophysiological Mechanisms of Thrombosis in Myeloproliferative Neoplasms.Current hematologic malignancy reports · 2021Review
- Growth Hormone and Neuronal Hemoglobin in the Brain-Roles in Neuroprotection and Neurodegenerative Diseases.Frontiers in endocrinology · 2020Review
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Authors and funding
11 authors at 8 institutions in 5 countries.
Funding
Abstract
introductionThere are conflicting results whether elevated hematocrit is associated with an increased risk of thromboembolic events in individuals without polycythemia vera. To assess the risk of vascular events in relation to hemoglobin concentration, we conducted a large population-based cohort study based on Scandinavian health registers. MATERIALS AND
methodsWe included 1,538,019 Swedish and Danish blood donors between 1987 and 2012. Hazard ratios (HRs) of arterial and venous thrombosis were estimated using Cox regression. Additionally, we fitted person-stratified models where each donor was compared only to him-/herself.
resultsThe risk of myocardial infarction and ischemic stroke increased with higher hemoglobin concentration in both men and women. The HRs for myocardial infarction and ischemic stroke in men with hemoglobin concentration ≥ 17.5 g/dL were 3.52 (95% confidence interval [CI], 2.85-4.36) and 2.36 (95% CI, 1.63-3.43), respectively, compared to the reference group. The corresponding HRs for women with hemoglobin concentration ≥ 16.0 g/dL were 3.22 (2.12-4.89) and 2.35 (1.37-4.02) for myocardial infarction and ischemic stroke, respectively. The risk of venous thrombosis was highest in men with subnormal hemoglobin concentration (<13.0 g/dL), HR 1.69 (95% CI, 1.40-2.04). In the person-stratified model, the association between elevated hemoglobin concentration and risk of myocardial infarction was attenuated but remained significant.
conclusionsIn this large cohort of Scandinavian blood donors, elevated hemoglobin concentration was associated with an increased risk of vascular events, primarily arterial events. Even though associations were weakened when each person served as their own control, a high hemoglobin concentration may serve as a cardiovascular risk marker.
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