Evidence map›Paper›PMID 31927035›Full record

ArticleCellular signalling2020

Skip is essential for Notch signaling to induce Sox2 in cerebral arteriovenous malformations.

Daoqin Zhang, Xiaojing Qiao, Lumin Wang, Li Zhang, Jiayi Yao, Xiuju Wu, Tongtong Yu, Kristina I Boström, Yucheng Yao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Daoqin ZhangDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Xiaojing QiaoDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Lumin WangDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA; Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Li ZhangDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Jiayi YaoDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Xiuju WuDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA.
Tongtong YuDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA; Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, China.
Kristina I BoströmDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA; The Molecular Biology Institute at UCLA, Los Angeles, CA 90095-1570, USA. Electronic address: kbostrom@mednet.ucla.edu.
Yucheng YaoDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA. Electronic address: yyao@mednet.ucla.edu.
University of California, Los Angeles · USChina Medical University · CNXi'an Jiaotong University · CN

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
Molecular Mechanisms of MGP; Role in AVMsR01HL081397 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2006 to 2025
$7.7M
BMP and Notch Crosstalk in Cerebral Arteriovenous MalformationsR01NS079353 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2012 to 2026
$5.3M
Switch of Osteogenesis in Vascular CalcificationR01HL139675 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2018 to 2026
$3.6M
NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R01 HL081397NHLBI NIH HHS R01 HL139675NINDS NIH HHS R01 NS079353
6 · The paper itself

Abstract

Notch signaling and Sry-box (Sox) family transcriptional factors both play critical roles in endothelial cell (EC) differentiation in vascularization. Recent studies have shown that excessive Notch signaling induces Sox2 to cause cerebral arteriovenous malformations (AVMs). Here, we examine human pulmonary AVMs and find no induction of Sox2. Results of epigenetic studies also show less alteration of Sox2-DNA binding in pulmonary AVMs than in cerebral AVMs. We identify high expression of ski-interacting protein (Skip) in brain ECs, a Notch-associated chromatin-modifying protein that is lacking in lung ECs. Knockdown of Skip abolished Notch-induction of Sox2 in brain ECs, while restoration of Skip in lung ECs enabled Notch-mediated Sox2 induction. The results suggest that Skip is a key factor for induction of Sox2 in cerebral AVMs.

Indexed as

Signal TransductionAnimalsBrainDNAEndothelial CellsHumansIntracranial Arteriovenous MalformationsLungMice, Inbred C57BLModels, BiologicalNuclear Receptor CoactivatorsProtein BindingProteinsPulmonary ArteryReceptors, NotchSOXB1 Transcription FactorsDNAgranuloma protein, mouseNuclear Receptor CoactivatorsProteinsReceptors, NotchSkiip protein, mouseSNW1 protein, humanSOXB1 Transcription FactorsTranscription Factors

Identifiers

PMID31927035
PMCPMC7147809
OpenAlexW2998912702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.