Evidence map›Paper›PMID 31926943›Full record

ArticlePhysiology & behavior2020

Early postnatal decabromodiphenyl ether exposure reduces thyroid hormone and astrocyte density in the juvenile mouse dentate gyrus.

Caitlyn M Edwards, Deena Small, Tyler Bell, Julian David-Drori, Christina Hansen, Keith Morris-Schaffer, Charlene Canale, John Ng, Vincent P Markowski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Toxic Effects and Mechanisms of Polybrominated Diphenyl Ethers.International journal of molecular sciences · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Caitlyn M EdwardsDepartment of Psychology, State University of New York at Geneseo, Geneseo, NY 14454, United States.
Deena SmallDepartment of Biochemistry, University of New England, Biddeford, ME 04005, United States.
Tyler BellDepartment of Psychology, State University of New York at Geneseo, Geneseo, NY 14454, United States.
Julian David-DroriDepartment of Psychology, State University of New York at Geneseo, Geneseo, NY 14454, United States.
Christina HansenDepartment of Psychology, State University of New York at Geneseo, Geneseo, NY 14454, United States.
Keith Morris-SchafferDepartment of Psychology, State University of New York at Geneseo, Geneseo, NY 14454, United States.
Charlene CanaleDepartment of Psychology, State University of New York at Geneseo, Geneseo, NY 14454, United States.
John NgDepartment of Psychology, State University of New York at Geneseo, Geneseo, NY 14454, United States.
Vincent P MarkowskiDepartment of Psychology, State University of New York at Geneseo, Geneseo, NY 14454, United States. Electronic address: markowski@geneseo.edu.
SUNY Geneseo · USUniversity of New England · US

Funding

Effect of Polybrominated Diphenal Ether Flame Retardant Exposure on OsteogenesisR15ES018958 · NIEHS · UNIVERSITY OF NEW ENGLAND · PI SMALL, DEENA J · 2010 to 2010
$197k
NIEHS NIH HHS R15 ES018958
6 · The paper itself

Abstract

Decabromodiphenyl ether (decaBDE) is a flame retardant that was widely-applied to many consumer products for decades. Consequently, decaBDE and other members of its class have become globally-distributed environmental contaminants. Epidemiological and animal studies indicate that decaBDE exposure during critical periods of brain development produces long-term behavioral impairments. The current study was designed to identify potential neuroendocrine mechanisms for learning and response inhibition deficits observed by our lab in a previous study. C57BL6/J mouse pups were given a single daily oral dose of 0 or 20 mg/kg decaBDE from day 1 to 21. Serum thyroid hormone levels and astrocyte-specific staining in three regions of the hippocampus were measured on day 22. DecaBDE exposure significantly reduced serum triiodothyronine, thyroxine, and astrocyte density in the subgranular zone but not the hilus or granular layer in both male and female mice. The reduction of thyroid hormone and/or glia activity could impair hippocampal development, leading to behavior dysfunction.

Indexed as

AnimalsAnimals, NewbornAstrocytesCell CountDentate GyrusDose-Response Relationship, DrugFemaleHalogenated Diphenyl EthersMaleMiceMice, Inbred C57BLNeurogliaThyroid HormonesThyroxineTriiodothyroninedecabromobiphenyl etherHalogenated Diphenyl EthersThyroid HormonesThyroxineTriiodothyronineAstrocyteDecabromodiphenyl etherDentate gyrusFlame retardantGFAPHippocampus

Identifiers

PMID31926943
PMCPMC7905994
OpenAlexW2998984165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.