ArticleRedox biology2020
Multiple plasma metals, genetic risk and serum C-reactive protein: A metal-metal and gene-metal interaction study.
Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Environmental Toxic Metals and Metalloids Exposure and Cardiovascular Health: Current Evidence from Oxidative Stress and Inflammatory Biomarkers as Indicators of Subclinical Cardiovascular Effects.Antioxidants (Basel, Switzerland) · 2026Review
- Association Between Metal Mixtures and C-Reactive Protein Levels: A Study Based on Occupational Populations in China.Biological trace element research · 2026Article
- Association of maternal multiple serum metal/metalloid concentrations and metabolic gene polymorphisms with offspring skeletal defects: a multicenter case-control study.BMC pregnancy and childbirth · 2026Article
- Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study.Environment & health (Washington, D.C.) · 2026Article
- Association of dietary intake and whole blood essential trace elements with frailty in older adults: a cross-sectional study.Aging clinical and experimental research · 2025Article
- Cardiomyocyte regeneration after infarction: changes, opportunities and challenges.Molecular and cellular biochemistry · 2025Review
- Associations of essential trace metals with telomere length in general population: a cross-sectional study.Scientific reports · 2025Article
- Socioeconomic position interacts with the genetic effect of a CRP gene common variant to influence C-reactive protein values.Scientific reports · 2024Article
- Suicidality and its associated factors among mood disorder patients in emergency department in China: a comparative study using propensity score matching approach.Translational psychiatry · 2023Article
- Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke.Nutrients · 2023Article
- The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China.Frontiers in public health · 2023Article
- The relationship of genetic risk score with cardiometabolic risk factors: a cross-sectional study.BMC cardiovascular disorders · 2022Article
- Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Review
- Serum Indicators of Oxidative Damage from Embedded Metal Fragments in a Rat Model.Oxidative medicine and cellular longevity · 2022Article
- Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older.The Science of the total environment · 2021Article
- Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome.Clinical epigenetics · 2021Article
- Inhibitors of Src Family Kinases, Inducible Nitric Oxide Synthase, and NADPH Oxidase as Potential CNS Drug Targets for Neurological Diseases.CNS drugs · 2021Review
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundC-reactive protein (CRP) is a well-recognized biomarker of inflammation, which can be used as a predictor of cardiovascular disease. Evidence have suggested exposure to multiple metals/metalloids may affect immune system and give rise to cardiovascular disease. However, it is lack of study to comprehensively evaluate the association of multiple metals and CRP, the interactions between metals, and the gene-metal interaction in relation to CRP levels.
aimsTo explore the associations of multiple plasma metals with serum CRP, and to test the interactions between metals, and gene-metal interactions on the levels of serum CRP.
methodsWe included 2882 participants from the Dongfeng-Tongji cohort, China, and measured 23 plasma metals and serum CRP concentrations. The genetic risk score (GRS) was calculated based on 7 established CRP-associated variants. For metals which were associated with the levels of CRP, we further tested the interactions between metals on CRP, and analyzed the gene-metal interactions on CRP.
resultsThe median level for CRP in the total population was 1.17 mg/L. After multivariable adjustment, plasma copper was positively associated with serum CRP (FDR < 0.001), whereas selenium was negatively associated with serum CRP (FDR = 0.01). Moreover, selenium and zinc attenuated the positive association between high plasma copper and CRP (P for interaction < 0.001). Participants with a higher GRS had a higher CRP level, with the increase in ln-transformed CRP per increment of 5 risk alleles were 0.64 for weighted GRS, and 0.54 for unweighted GRS (both P < 0.001). Furthermore, the genetic association with CRP was modified by copper concentration (P for interaction < 0.001).
conclusionsOur results suggest that serum CRP is positively associated with plasma concentration of copper, and inversely associated with selenium. Plasma zinc, selenium and CRP genetic predisposition would modify the associations between plasma copper and serum CRP.
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