Evidence map›Paper›PMID 31926601›Full record

ArticleTrends in pharmacological sciences2020

Drug Screen Tugs at Common Thread for Repeat Disorders.

Kaalak Reddy, John Douglas Cleary, J Andrew Berglund

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kaalak ReddyRNA Institute, State University of New York at Albany, Albany, NY, USA.
John Douglas ClearyRNA Institute, State University of New York at Albany, Albany, NY, USA.
J Andrew BerglundRNA Institute, State University of New York at Albany, Albany, NY, USA; Department of Biological Sciences, State University of New York at Albany, Albany, NY, USA. Electronic address: aberglund@albany.edu.
University at Albany, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeat-associated non-ATG (RAN) translation is emerging as a driver of pathogenesis in microsatellite expansion disorders. Green and colleagues recently identified several candidate RAN translation inhibitors from a high-throughput small-molecule screen for fragile X tremor ataxia syndrome. Their study establishes a path forward for identifying inhibitors of RAN translation for multiple disorders.

Indexed as

Fragile X Messenger Ribonucleoprotein 1Fragile X SyndromeAtaxiaHumansTremorTrinucleotide Repeat ExpansionFragile X Messenger Ribonucleoprotein 1multiple targetsRAN translationRNA bindingtherapeutic compound screen

Identifiers

PMID31926601
OpenAlexW3000520805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.