Evidence map›Paper›PMID 31926590›Full record

ArticleJournal of biomechanics2020

Evaluation of human nasal cartilage nonlinear and rate dependent mechanical properties.

Brian Chang, Chelsea Reighard, Colleen Flanagan, Scott Hollister, David Zopf

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07717138 (Study of the Biomechanical and Histological Properties of Septal, Auricular, and Costal Cartilage in the Context of Optimizing Total Nasal Reconstruction), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07717138 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Study of the Biomechanical and Histological Properties of Septal, Auricular, and Costal Cartilage in the Context of Optimizing Total Nasal Reconstruction

TypeobservationalSponsorHôpital NOVORan2026 to 2026Enrolled33ConditionsSeptoplasty, Rhinoseptoplasty, Rib Grafting, OtoplastyArmsAnalysis of the biomechanical properties of septal cartilage as well as the cartilages used in nasal reconstruction and their histological identification.
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Multiscale Strain Transfer in Cartilage.Frontiers in cell and developmental biology · 2022
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brian ChangUniversity of Michigan Medical School, 1500 East Hospital Drive, Ann Arbor, MI 48109, USA.
Chelsea ReighardUniversity of Michigan Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, 1000 Wall Street, Ann Arbor, MI 48105, USA.
Colleen FlanaganDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd., Ann Arbor, MI 48109, USA.
Scott HollisterCoulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive, Atlanta, GA 30332, USA. Electronic address: scott.hollister@bme.gatech.edu.
David ZopfDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd., Ann Arbor, MI 48109, USA; Department of Otolaryngology - Head and Neck Surgery, CS Mott Children's Hospital, 1540 East Hospital Drive, Ann Arbor, MI 48109, USA. Electronic address: davidzop@med.umich.edu.
University of Michigan · USGeorgia Institute of Technology · US

Funding

NRSA Training CoreTL1TR002242 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLINSTAT, MICHAEL ALLAN · 2017 to 2021
$2.8M
NCATS NIH HHS TL1 TR002242
6 · The paper itself

Abstract

Nasal reconstruction frequently requires donor cartilage and tissue, and ideally, donor tissue will closely emulate native nasal cartilage mechanics. Tissue engineering scaffolds, especially 3D printed scaffolds, have been proposed for nasal reconstruction, and the success of these constructs may depend on how well scaffolds reflect native nasal cartilage mechanical properties. Therefore, consistent and comprehensive characterization of native nasal cartilage mechanical properties is a foundation for nasal cartilage tissue engineering and reconstruction in general by providing design targets for reconstructive materials. Our group has previously shown the feasibility of producing scaffolds with porous architecture permitting chondrocyte growth and cartilage production. In this study, we determined the nonlinear and stress relaxation behavior of human nasal cartilage under unconfined compression. We then fit this experimental data to nonlinear elastic, nonlinear viscoelastic and nonlinear biphasic constitutive models. The resulting coefficients will provide design targets for nasal reconstruction and scaffold design as well as outcome measures for assessment of tissue engineered nasal cartilage.

Indexed as

Mechanical PhenomenaNasal CartilagesNonlinear DynamicsBiomechanical PhenomenaChondrocytesHumansKineticsPorosityPressureStress, MechanicalBiomechanicsCartilage computational modelingNasal cartilageNasal tissue engineeringNonlinear elasticity

Identifiers

PMID31926590
PMCPMC8041261
OpenAlexW2990647796

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.