Evidence map›Paper›PMID 31926575›Full record

ArticleThe Permanente journal2019

Predictive Factors for Early Relapse in Multiple Myeloma after Autologous Hematopoietic Stem Cell Transplant.

Andrew Mayer Pourmoussa, Ricardo Spielberger, Jilian Cai, Odelia Khoshbin, Leonardo Farol, Thai Cao, Firoozeh Sahebi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Permanente journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew Mayer PourmoussaDepartment of Internal Medicine, Los Angeles Medical Center, CA.
Ricardo SpielbergerBone Marrow Transplant Department, Los Angeles Medical Center, CA.
Jilian CaiBone Marrow Transplant Department, Los Angeles Medical Center, CA.
Odelia KhoshbinCollege of Osteopathic Medicine, Western University of Health Sciences, Pomona, CA.
Leonardo FarolBone Marrow Transplant Department, Los Angeles Medical Center, CA.
Thai CaoBone Marrow Transplant Department, Los Angeles Medical Center, CA.
Firoozeh SahebiBone Marrow Transplant Department, Los Angeles Medical Center, CA.
Los Angeles Medical Center · USWestern University of Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite advances in therapy for multiple myeloma, patients have continued to experience relapse. We sought to better understand this.

objectiveTo identify factors that predict early relapse in patients with multiple myeloma who receive autologous hematopoietic peripheral stem cell transplant (HSCT).

methodsRetrospective analysis of Kaiser Permanente Southern California patients who received HSCTs between 2008 and 2012.

resultsA total of 141 patients were included. Factors found to be associated with inferior progression-free survival were disease status less than complete response at the time of HSCT, no use of maintenance therapy after HSCT, International Staging System stage III, and high Freiburg Comorbidity Index. Disease status less than complete response, stage III, higher Freiburg Comorbidity Index, no use of maintenance therapy, and male sex were the most predictive factors for early relapse (< 18 months). DISCUSSION: Our results identified a subgroup of high-risk individuals with multiple myeloma who will continue to do poorly after HSCT with the best available treatment using a combination of proteasome inhibitors and immunomodulatory drugs. These results highlight the need for consideration of alternative therapy in such instances.

Indexed as

AdultAgedAge FactorsComorbidityDisease-Free SurvivalFemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedMultiple MyelomaNeoplasm StagingRecurrenceRetrospective StudiesSeverity of Illness IndexSex Factors

Identifiers

PMID31926575
PMCPMC6836627
OpenAlexW3003225247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.