Evidence map›Paper›PMID 31926484›Full record

Trial reportPediatric research2020

Body composition and neuromotor development in the year after NICU discharge in premature infants.

Dan M Cooper, Gay L Girolami, Brenda Kepes, Annamarie Stehli, Candice Taylor Lucas, Fadia Haddad, Frank Zalidvar, Nitzan Dror, Irfan Ahmad, Antoine Soliman and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Dan M CooperPediatric Exercise and Genomics Research Center, UC Irvine School of Medicine, Irvine, CA, USA. dcooper@hs.uci.edu.
Gay L GirolamiDepartment of Physical Therapy, University of Illinois at Chicago, Chicago, IL, USA.
Brenda KepesPediatric Exercise and Genomics Research Center, UC Irvine School of Medicine, Irvine, CA, USA.
Annamarie StehliPediatric Exercise and Genomics Research Center, UC Irvine School of Medicine, Irvine, CA, USA.
Candice Taylor LucasPediatric Exercise and Genomics Research Center, UC Irvine School of Medicine, Irvine, CA, USA.
Fadia HaddadPediatric Exercise and Genomics Research Center, UC Irvine School of Medicine, Irvine, CA, USA.
Frank ZalidvarPediatric Exercise and Genomics Research Center, UC Irvine School of Medicine, Irvine, CA, USA.
Nitzan DrorPediatric Exercise and Genomics Research Center, UC Irvine School of Medicine, Irvine, CA, USA.
Irfan AhmadChildren's Hospital of Orange County, Orange, CA, USA.
Antoine SolimanMiller Women's and Children's Hospital, Long Beach, CA, USA.
Shlomit Radom-AizikPediatric Exercise and Genomics Research Center, UC Irvine School of Medicine, Irvine, CA, USA.
University of California, Irvine · USChildren's Hospital of Orange County · USMiller Children's & Women's Hospital · USUniversity of Illinois Chicago · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Impact of Exercise on Body Composition in Premature Infants: New ApproachesR01HL110163 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2011 to 2016
$2.6M
NCATS NIH HHS UL1 TR001414NHLBI NIH HHS R01 HL110163
6 · The paper itself

Abstract

backgroundHypothesis: neuromotor development correlates to body composition over the first year of life in prematurely born infants and can be influenced by enhancing motor activity.

methodsForty-six female and 53 male infants [27 ± 1.8 (sd) weeks] randomized to comparison or exercise group (caregiver provided 15-20 min daily of developmentally appropriate motor activities) completed the year-long study. Body composition [lean body and fat mass (LBM, FM)], growth/inflammation predictive biomarkers, and Alberta Infant Motor Scale (AIMS) were assessed.

resultsAIMS at 1 year correlated with LBM (r = 0.32, p < 0.001) in the whole cohort. However, there was no effect of the intervention. LBM increased by ~3685 g (p < 0.001)); insulin-like growth factor-1 (IGF-1) was correlated with LBM (r = 0.36, p = 0.002). IL-1RA (an inflammatory biomarker) decreased (-75%, p < 0.0125). LBM and bone mineral density were significantly lower and IGF-1 higher in the females at 1 year.

conclusionsWe found an association between neuromotor development and LBM suggesting that motor activity may influence LBM. Our particular intervention was ineffective. Whether activities provided largely by caregivers to enhance motor activity in prematurely born infants can affect the interrelated (1) balance of growth and inflammation mediators, (2) neuromotor development, (3) sexual dimorphism, and/or (4) body composition early in life remains unknown.

Indexed as

Body CompositionIntensive Care Units, NeonatalAbsorptiometry, PhotonAdipose TissueBiomarkersBody Mass IndexBone DensityBrainCohort StudiesFemaleFollow-Up StudiesHuman Growth HormoneHumansInfantInfant, NewbornInfant, PrematureBiomarkersHuman Growth Hormone

Identifiers

PMID31926484
PMCPMC7351612
OpenAlexW3000628938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.