ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Polygenic prediction and GWAS of depression, PTSD, and suicidal ideation/self-harm in a Peruvian cohort.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review.Biological psychiatry · 2026Pooled it
- Genetic variation associated with depression in Latin American populations: a systematic review of single-nucleotide variants.Frontiers in psychiatry · 2026Pooled it
- Genome-wide association study meta-analysis of suicide death and suicidal behavior.Molecular psychiatry · 2023Pooled it
- Famine Exposure during Early Life and Risk of Cancer in Adulthood: A Systematic Review and Meta-Analysis.The journal of nutrition, health & aging · 2023Pooled it
- Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Pooled it
- Joint Effects of Adverse Childhood Experiences and Genetic Burden of Depression on Multiple Depressive Symptoms.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- A phenome-wide association and Mendelian randomization study for suicide attempt within UK Biobank.Molecular psychiatry · 2026Article
- Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.Molecular psychiatry · 2026Article
- Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children.Nature communications · 2025Article
- Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal.Psychological medicine · 2024Article
- Prevalence of perinatal post-traumatic stress disorder (PTSD) in low-income and middle-income countries: a systematic review and meta-analysis.BMJ public health · 2024Article
- Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.Nature genetics · 2024Article
- Article
- The association of mindfulness and psychological well-being among individuals who have recovered from COVID-19 in Jianghan District, Wuhan, China: A cross-sectional study.Journal of affective disorders · 2022Article
- Suicide Risk in Military Personnel during the COVID-19 Health Emergency in a Peruvian Region: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- A Race-Conscious Approach Toward Research on Racial Inequities in Palliative Care.Journal of pain and symptom management · 2022Article
- Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide.JAMA network open · 2022Article
- A Polygenic Approach to Understanding Resilience to Peer Victimisation.Behavior genetics · 2022Article
- From genetics to systems biology of stress-related mental disorders.Neurobiology of stress · 2021Article
- Genetic contributions to suicidal thoughts and behaviors.Psychological medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
Abstract
Genome-wide approaches including polygenic risk scores (PRSs) are now widely used in medical research; however, few studies have been conducted in low- and middle-income countries (LMICs), especially in South America. This study was designed to test the transferability of psychiatric PRSs to individuals with different ancestral and cultural backgrounds and to provide genome-wide association study (GWAS) results for psychiatric outcomes in this sample. The PrOMIS cohort (N = 3308) was recruited from prenatal care clinics at the Instituto Nacional Materno Perinatal (INMP) in Lima, Peru. Three major psychiatric outcomes (depression, PTSD, and suicidal ideation and/or self-harm) were scored by interviewers using valid Spanish questionnaires. Illumina Multi-Ethnic Global chip was used for genotyping. Standard procedures for PRSs and GWAS were used along with extra steps to rule out confounding due to ancestry. Depression PRSs significantly predicted depression, PTSD, and suicidal ideation/self-harm and explained up to 0.6% of phenotypic variation (minimum p = 3.9 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.