ArticleAmerican journal of ophthalmology2020
Visual Function and Disability Are Associated with Increased Retinal Volumetric Vessel Density in Patients with Multiple Sclerosis.
Article in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis.Journal of neuroinflammation · 2023Pooled it
- Quantitative ophthalmic posterior segment optical coherence tomography angiography and neurologic conditions: a review.Frontiers in neurologyPooled it
- Reduced Retinal Perfusion With Preserved Microvascular Network Density in Early Alzheimer's Disease: A Multimodal Imaging Study.Translational vision science & technology · 2026Article
- Optical Coherence Tomography Angiography Findings in Primary Progressive Multiple Sclerosis Patients Receiving Ocrelizumab Treatment.Diagnostics (Basel, Switzerland) · 2026Article
- Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults.PloS one · 2026Article
- Longitudinal analysis of retinal and choriocapillaris in patients with multiple sclerosis: a 3-year study.Journal of neurology · 2025Article
- Barriers in Healthcare to the Use of Optical Coherence Tomography Angiography in Multiple Sclerosis.Neurology and therapy · 2025Review
- Optical coherence tomography angiography as a potential tool in differential diagnosis of multiple sclerosis and rheumatic disorders with central nervous system involvement.International ophthalmology · 2024Article
- Dissociation of retinal ganglion cell complex and superficial retinal vessel density on optical coherence tomography in a case of pediatric optic neuritis.American journal of ophthalmology case reports · 2023Article
- Review
- Utility of the visual system to monitor neurodegeneration in multiple sclerosis.Frontiers in molecular neuroscience · 2023Review
- Retinal imaging with optical coherence tomography in multiple sclerosis: novel aspects.Wiener medizinische Wochenschrift (1946) · 2022Review
- Microvascular changes in the macular and parafoveal areas of multiple sclerosis patients without optic neuritis.Scientific reports · 2022Article
- Optical Coherence Tomography and Optical Coherence Tomography with Angiography in Multiple Sclerosis.Healthcare (Basel, Switzerland) · 2022Review
- Schizophrenia in Translation: Why the Eye?Schizophrenia bulletin · 2022Article
- Impact of signal strength on quantitative retinal and choriocapillaris flow measurement from optical coherence tomography angiography.Scientific reports · 2022Article
- The Value of Optical Coherence Tomography Angiography (OCT-A) in Neurological Diseases.Diagnostics (Basel, Switzerland) · 2022Review
- Optical coherence tomography angiography characteristics and correlated factors with visual acuity in retinal arterial occlusion.International ophthalmology · 2022Article
- OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment.Frontiers in digital health · 2022Article
- Longitudinal Study of Retinal Structure, Vascular, and Neuronal Function in Patients With Relapsing-Remitting Multiple Sclerosis: 1-Year Follow-Up.Translational vision science & technology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThe goal of this study was to determine the volumetric vessel density (VVD) in the intraretinal layers and its relationship with visual function and disability in patients with multiple sclerosis (MS).
designCross-sectional study.
methodsA total of 80 patients with relapsing-remitting MS and 99 age- and sex-matched healthy controls (HC) were recruited. The retinal microvascular network in the macular area was imaged using optical coherence tomography angiography in 123 eyes without a history of optic neuritis (ON) (MSNON) and 36 eyes with a history of ON (MSON). The VVD was calculated as the vessel densities in the retinal vascular network (RVN), superficial vascular plexus (SVP), or deep vascular plexus (DVP) of an annulus (0.6-2.5 mm in diameter), divided by the corresponding tissue volume of the intraretinal layers respectively.
resultsThe VVD of RVN and DVP in MSNON were significantly higher than in HC (P < .05). The VVD of RVN, SVP, and DVP in MSON were significantly higher than in MSNON and HC (P < .05). The VVD in both RVN and SVP were positively related to EDSS and disease duration, but negatively related to low-contrast letter acuity (P < .05). The VVD measurements were also negatively and strongly related to the corresponding tissue volumes (P < .05).
conclusionsThis is the first study to reveal increased retinal VVD in patients with relapsing-remitting MS. The measurements of VVD in the RVN and SVP were related to disability and visual function, which may be developed as image markers for tracking disease progression.
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Registered trials
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