Evidence map›Paper›PMID 31925975›Full record

ArticleCancer science2020

Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation-associated renal tumors in Eker rats.

Tatsuya Inoue, Toshiaki Kokubo, Kazuhiro Daino, Hiromi Yanagihara, Fumiko Watanabe, Chizuru Tsuruoka, Yoshiko Amasaki, Takamitsu Morioka, Shino Homma-Takeda, Toshiyuki Kobayashi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Tatsuya InoueDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Toshiaki KokuboLaboratory Animal and Genome Sciences Section, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Kazuhiro DainoDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Hiromi YanagiharaDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Fumiko WatanabeDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Chizuru TsuruokaDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.ORCID https://orcid.org/0000-0002-2407-953X
Yoshiko AmasakiDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Takamitsu MoriokaDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Shino Homma-TakedaDepartment of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Toshiyuki KobayashiDepartment of Pathology and Oncology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Okio HinoDepartment of Pathology and Oncology, Faculty of Medicine, Juntendo University, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7592-7466
Yoshiya ShimadaNational Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Shizuko KakinumaDepartment of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.ORCID https://orcid.org/0000-0001-9635-8813
National Institutes for Quantum Science and Technology · JPJuntendo University · JP

Funding

Japan Society for the Promotion of Science 15H01834
6 · The paper itself

Abstract

Ionizing radiation can damage DNA and, therefore, is a risk factor for cancer. Eker rats, which carry a heterozygous germline mutation in the tumor-suppressor gene tuberous sclerosis complex 2 (Tsc2), are susceptible to radiation-induced renal carcinogenesis. However, the molecular mechanisms involved in Tsc2 inactivation are unclear. We subjected Fischer 344 × Eker (Long Evans Tsc2

Indexed as

AllelesAnimalsChromosome DeletionChromosomes, Human, Pair 10Comparative Genomic HybridizationGamma RaysHeterozygoteHumansKidney NeoplasmsMaleMutationRatsRats, Inbred F344Rats, Long-EvansRiskTuberous SclerosisTsc2 protein, ratTuberous Sclerosis Complex 2 ProteinTumor Suppressor ProteinsEker ratgenomic signatureionizing radiationrenal carcinomaTsc2

Identifiers

PMID31925975
PMCPMC7060461
OpenAlexW2999691538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.