ArticlePediatric blood & cancer2020
Practice patterns for stroke prevention using transcranial Doppler in sickle cell anemia: DISPLACE Consortium.
Article in Pediatric blood & cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Successful implementation of stroke risk screening for sickle cell anemia in the DISPLACE study: results of a cluster randomized trial.Implementation science : IS · 2025Trial
- Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers.Neuroimage. Reports · 2025Article
- DISPLACE study shows poor quality of transcranial doppler ultrasound for stroke risk screening in sickle cell anemia.Blood advances · 2024Article
- Practice Patterns for Addressing Developmental-Behavioral Concerns in Sickle Cell Specialty Care.Clinical practice in pediatric psychology · 2023Article
- Transcranial doppler as screening method for sickling crises in children with sickle cell anemia: a latin America cohort study.BMC pediatrics · 2022Article
- Practice patterns for neuroimaging and transfusion therapy for management of neurologic complications in sickle cell anemia: DISPLACE consortium.Pediatric blood & cancer · 2020Article
- Pre-transplant imaging evaluation in sickle cell disease: recommended protocols before allogeneic hematopoietic stem cell transplantation.Radiologia brasileiraReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChildren with sickle cell anemia (SCA) are at increased risk for stroke. In 2014, the National Heart, Lung, and Blood Institute (NHLBI) developed guidelines for stroke prevention in SCA informed by the Stroke Prevention Trial in Sickle Cell Anemia (STOP) and Optimizing Primary Stroke Prevention in Sickle Cell Anemia (STOP II) trials. The guidelines specify the use of transcranial Doppler (TCD) screening and intervention with chronic red cell transfusions (CRCT) in children with SCA who have TCD indication of high stroke risk. The purpose of this study was to describe real-world practice patterns of stroke risk screening and intervention in sites that participated in the Dissemination and Implementation of Stroke Prevention Looking at the Care Environment (DISPLACE) Consortium. PROCEDURE: Site investigators completed a survey during the formative stages of the study to evaluate their TCD practices relative to the STOP studies. Descriptive statistics and analysis of free-text comments for more complex practices were evaluated.
resultsResults suggested universal acceptance of annual TCD screening and initiation of CRCT following an abnormal result among the DISPLACE Consortium, consistent with NHLBI recommendations. However, there was wide variation in methods for conducting TCD screenings (eg, dedicated Doppler vs TCD imaging), classifying TCD results, and actions taken for conditional and inadequate results.
conclusionsAnnual TCD screening and initiation of CRCT are critical stroke prevention practices that were universally embraced in the consortium. Additional research would be beneficial for informing clinical practices for areas in which guidelines are absent or unclear.
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