ReviewHuman brain mapping2020
Tractostorm: The what, why, and how of tractography dissection reproducibility.
Review in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of automated methods to perform white matter tract segmentation.Frontiers in neuroscience · 2024Pooled it
- Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review.Journal of neuro-oncology · 2023Pooled it
- Air-jet Pneumodissection in Neuroanatomy: a new method for the study of White Matter anatomy in the Human Brain.Anatomical science international · 2026Article
- Graph-Based White Matter Tractometry: Methods, Applications, and the Path to Validation.Neuroinformatics · 2026Review
- Gamma knife thalamotomy for essential tremor in the third era of functional neurosurgery.Neurosurgical review · 2026Observational
- Bridging Histology and Tractography: First In Vivo Visualization of Short-Range Prefrontal Connections Informed by Primate Tract-Tracing.Human brain mapping · 2026Article
- Did you know? State-of-the-art preprocessing diffusion MRI data can improve tractography.Brain structure & function · 2026Review
- What needs to be standardized for reliable, reproducible, and robust tractography?GigaScience · 2026Review
- Brain dissection photogrammetry: a tool for studying human white matter connections integrating ex vivo and in vivo multimodal datasets.Nature communications · 2025Article
- Bridging Histology and Tractography: First Visualization of the Short-Range Prefrontal Connections in the Human Brain.bioRxiv : the preprint server for biology · 2025Article
- Atlas-based templates vs. subject-specific tractography: resolving the debate.Brain structure & function · 2025Review
- ER-detect: A pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.Journal of neuroscience methods · 2025Article
- Comparison of structural connectomes for modeling deep brain stimulation pathway activation.NeuroImage · 2025Article
- Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.Brain structure & function · 2025Article
- A window into the brain: multimodal MRI assessment of vascular cognitive impairment.Frontiers in neuroscience · 2025Review
- Artificial intelligence in corticospinal tract segmentation using constrained spherical deconvolution.Surgical neurology international · 2025Article
- Changing the Paradigm for Tractography Segmentation in Neurosurgery: Validation of a Streamline-Based Approach.Brain sciences · 2024Article
- Sex-related variability of white matter tracts in the whole HCP cohort.Brain structure & function · 2024Article
- Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.bioRxiv : the preprint server for biology · 2024Article
- Multimodal study of multilevel pulvino-temporal connections: a new piece in the puzzle of lexical retrieval networks.Brain : a journal of neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called "virtual dissection." Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. It is our opinion that if the field of dMRI tractography wants to be taken seriously as a widespread clinical tool, it is imperative to harmonize WM bundle segmentations and develop protocols aimed to be used in clinical settings. The EADC-ADNI Harmonized Hippocampal Protocol achieved such standardization through a series of steps that must be reproduced for every WM bundle. This article is an observation of the problematic. A specific bundle segmentation protocol was used in order to provide a real-life example, but the contribution of this article is to discuss the need for reproducibility and standardized protocol, as for any measurement tool. This study required the participation of 11 experts and 13 nonexperts in neuroanatomy and "virtual dissection" across various laboratories and hospitals. Intra-rater agreement (Dice score) was approximately 0.77, while inter-rater was approximately 0.65. The protocol provided to participants was not necessarily optimal, but its design mimics, in essence, what will be required in future protocols. Reporting tractometry results such as average fractional anisotropy, volume or streamline count of a particular bundle without a sufficient reproducibility score could make the analysis and interpretations more difficult. Coordinated efforts by the diffusion MRI tractography community are needed to quantify and account for reproducibility of WM bundle extraction protocols in this era of open and collaborative science.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.