ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2020
Fertility factors affect the vaginal microbiome in women of reproductive age.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed, 56 citations in OpenAlex.
- Safety assessment scheme for menstrual cups and application for the evaluation of a menstrual cup comprised of medical grade silicone.EBioMedicine · 2022Trial
- A negative binomial latent factor model for paired microbiome sequencing data.BMC bioinformatics · 2026Article
- Critical role of reproductive tract microbiota and derived metabolites in inflammation, tumor immunity, and tumorigenesis of gynecological cancers: a narrative review.Frontiers in immunology · 2026Review
- The hormone-microbiota-NET framework in gynecologic diseases: evidence, controversies, and translational opportunities.Frontiers in immunology · 2026Review
- Vaginal microbial community state types fail to predict IVF outcomes, whereasHuman reproduction open · 2026Article
- Differences in Vaginal Microbiota Composition Between Infertile and Fertile Patients: A Prospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- Correlation between Escherichia coli infection during pregnancy and maternal-fetal outcomes: a retrospective analysis.BMC infectious diseases · 2025Article
- All Properties of Infertility Microbiome in a Review Article.Journal of clinical laboratory analysis · 2025Review
- Uterine Microbiota and Bisphenols: Novel Influencers in Reproductive Health.Journal of xenobiotics · 2025Review
- Microbiota Dysbiosis: A Key Modulator in Preeclampsia Pathogenesis and Its Therapeutic Potential.Microorganisms · 2025Review
- Effects of Aging on the Microbiota and Inflammatory Status of the Intestinal and Oviductal Mucosa in Laying Hens.The journal of poultry science · 2025Article
- Navigating the Microbial Landscape: Understanding Dysbiosis in Human Genital Tracts and Its Impact on Fertility.Cureus · 2024Review
- Significant increased isolation of Escherichia coli in Iranian women with endometriosis: a case control - study.BMC women's health · 2024Article
- Gut microbiota-metabolite interactions meditate the effect of dietary patterns on precocious puberty.iScience · 2024Article
- Dynamic principles of the microbiome and the bovine vagina: a review.Frontiers in microbiology · 2024Review
- Special series on the role of the microbiome in reproduction and fertility.Reproduction & fertility · 2023Article
- Vaginal Infections during Pregnancy Increase Breast Milk Microbiome Alpha Diversity and Alter Taxonomic Composition.Preventive nutrition and food science · 2023Article
- Microbiota metabolites in the female reproductive system: Focused on the short-chain fatty acids.Heliyon · 2023Review
- Commensal Lactobacilli Metabolically Contribute to Cervical Epithelial Homeostasis in a Species-Specific Manner.mSphere · 2023Article
- Beyond the Gut, Emerging Microbiome Areas of Research: A Focus on Early-Life Microbial Colonization.Microorganisms · 2023Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
problemFor women of reproductive age, achieving a successful pregnancy requires both the normal functioning of reproductive endocrine and the health of the reproductive tract environment. We aimed to study how these fertility factors, such as female age, baseline sexual hormone levels, tubal patency, and vaginal pH, affect the composition of vaginal microbiome. METHOD OF STUDY: The 16S rRNA sequencing was carried on vaginal microbiome samples from 85 women of reproductive age without vaginal infections or reproductive endocrine diseases. The detailed correlations between fertility factors and vaginal microbiome were quantified by Spearman's rank tests. A linear discriminant analysis was carried out to explore the effects of fertility factors on the relative abundances of vaginal bacterial species.
resultsThe vaginal pH, levels of basal E2, LH, and FSH all had significant effects on the distribution of vaginal microbiome. The relative abundances of vaginal bacterial species, including Escherichia coli, Streptococcus agalactiae, and Prevotella intermedia, were significantly different due to the host's state of reproductive endocrine and tubal patency. It was worth noting that women with tubal obstruction, or prolonged menstrual cycle, or antral follicle count >15, or vaginal pH > 4.5 all had a higher abundance of Escherichia coli in vagina.
conclusionThe fertility factors associated with the reproductive endocrine and the genital tract environment affected vaginal microbiome in women of reproductive age. The species Escherichia coli, Streptococcus agalactiae, Prevotella intermedia, etc could be used as biomarkers to reflect the pathological state of reproductive endocrine and genital tract.
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